Department of Dermatology, Icahn School of Medicine at Mount Sinai, 5 East 98th Street, 5th Floor, New York, NY 10028, USA.
Division of Adult Allergy and Immunology, Maimonides Medical Center, 4813 9th Avenue, 5th Floor, Brooklyn, NY 11219, USA.
Dermatol Clin. 2024 Oct;42(4):559-567. doi: 10.1016/j.det.2024.04.006. Epub 2024 Jun 3.
Patients with atopic dermatitis (AD) are at increased risk of atopic and non-atopic comorbidities. In fact, the Hanifin and Rajka criteria include allergic and infectious comorbidities as a minor criterion. Despite the well-recognized list of comorbidities, the past 15 years greatly expanded the list of recognized comorbidities of AD. This narrative review focuses on comorbidities of AD using a mnemonic, VINDICATE-P: vascular/cardiovascular, infectious, neoplastic and neurologic, degenerative, iatrogenic, congenital, atopic and autoimmune, traumatic, endocrine/metabolic, and psychiatric. The comorbidities of AD vary by age. More research is needed into the mechanisms of comorbidities and optimal screening strategies in AD patients.
特应性皮炎（AD）患者发生特应性和非特应性合并症的风险增加。事实上，Hanifin 和 Rajka 标准将过敏性和感染性合并症作为次要标准纳入其中。尽管公认的合并症清单，但在过去的 15 年中，AD 的公认合并症清单大大扩展。本综述使用记忆术 VINDICATE-P 来重点关注 AD 的合并症：血管/心血管、感染、肿瘤和神经、退行性、医源性、先天性、特应性和自身免疫、创伤、内分泌/代谢和精神。AD 的合并症随年龄而变化。需要进一步研究合并症的机制以及 AD 患者的最佳筛查策略。
