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营养代谢在调节肠道干细胞稳态中的作用。

Nutrient metabolism in regulating intestinal stem cell homeostasis.

机构信息

Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

Division of Nutritional Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

出版信息

Cell Prolif. 2024 Jun;57(6):e13602. doi: 10.1111/cpr.13602. Epub 2024 Feb 22.

DOI:10.1111/cpr.13602
PMID:38386338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11150145/
Abstract

Intestinal stem cells (ISCs) are known for their remarkable proliferative capacity, making them one of the most active cell populations in the body. However, a high turnover rate of intestinal epithelium raises the likelihood of dysregulated homeostasis, which is known to cause various diseases, including cancer. Maintaining precise control over the homeostasis of ISCs is crucial to preserve the intestinal epithelium's integrity during homeostasis or stressed conditions. Recent research has indicated that nutrients and metabolic pathways can extensively modulate the fate of ISCs. This review will explore recent findings concerning the influence of various nutrients, including lipids, carbohydrates, and vitamin D, on the delicate balance between ISC proliferation and differentiation.

摘要

肠干细胞（ISCs）以其显著的增殖能力而闻名，使其成为体内最活跃的细胞群体之一。然而，肠道上皮细胞的高周转率增加了失调的动态平衡的可能性，这是已知的导致各种疾病的原因，包括癌症。精确控制 ISCs 的动态平衡对于在动态平衡或应激条件下维持肠道上皮细胞的完整性至关重要。最近的研究表明，营养物质和代谢途径可以广泛调节 ISCs 的命运。本综述将探讨关于各种营养物质（包括脂质、碳水化合物和维生素 D）对 ISC 增殖和分化之间微妙平衡的影响的最新发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d85/11150145/814e319e3eb0/CPR-57-e13602-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d85/11150145/8ff8b74f993a/CPR-57-e13602-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d85/11150145/ca15b4432b61/CPR-57-e13602-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d85/11150145/70b819134394/CPR-57-e13602-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d85/11150145/874d1fd8cb32/CPR-57-e13602-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d85/11150145/7ea7e0b9e16c/CPR-57-e13602-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d85/11150145/814e319e3eb0/CPR-57-e13602-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d85/11150145/8ff8b74f993a/CPR-57-e13602-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d85/11150145/ca15b4432b61/CPR-57-e13602-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d85/11150145/70b819134394/CPR-57-e13602-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d85/11150145/874d1fd8cb32/CPR-57-e13602-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d85/11150145/7ea7e0b9e16c/CPR-57-e13602-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d85/11150145/814e319e3eb0/CPR-57-e13602-g007.jpg

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