Cherkasskaya Marina Valeryevna, Syrkashev Egor Mikhailovich, Sokolova Maria Valerievna, Petraikin Alexey Vladimirovich, Semenov Dmitry Sergeevich, Vasilev Yuri Aleksandrovich
State Budget-Funded Health Care Institution of the City of Moscow "Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department", Moscow, the Russian Federation.
FSBI "National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I.Kulakov", Moscow, the Russian Federation.
Quant Imaging Med Surg. 2024 Sep 1;14(9):6250-6259. doi: 10.21037/qims-24-501. Epub 2024 Aug 28.
Anthropomorphic phantoms play an important role in routine clinical practice. They can be used to calibrate magnetic resonance imaging (MRI) scanners, control the diagnostic equipment quality, and reduce the acquisition time. The latter is especially critical for diagnosing fetal anomalies, which requires optimal image quality within the shortest possible time. This paper aims to develop an MRI fetal phantom and determine the materials that best mimic the magnetic resonance (MR) characteristics of its internal organs. Future phantom features will include simulations of fetal limb movements.
A single MRI study of a pregnant woman at 20 weeks 3 days of gestation was used as a reference and for image segmentation. Anonymized Digital Imaging and Communication in Medicine (DICOM) files were imported into 3D Slicer v. 5.2.1 for segmentation of the uterus, fetus, and internal organs. Based on the performed segmentation, a three-dimensional model was obtained for printing on a 3D printer. The mold was 3D printed on an Anycubic Photon M3 Max printer. The paper showcases the selection and manufacturing of compositions to simulate the relaxation times of the fetal organs. Formulations for emulsions and carrageenan- and agar-based hydrogels are presented. The selected compositions were used to fill the 3D printed model.
Statistical analysis showed no significant differences in absolute and relative signal values obtained from scans of a pregnant woman at 20 weeks and 3 days and a fetal phantom.
During the study, an anthropomorphic fetal phantom was constructed, filled with compositions with relaxation times T1 and T2 similar to the control values of the corresponding tissues. The phantom can be used to set up and optimize fetal MRI protocols, train and educate medical students, residents, graduate students, and X-ray technicians, as well as to timely control image quality and equipment serviceability.
人体模型在日常临床实践中发挥着重要作用。它们可用于校准磁共振成像（MRI）扫描仪、控制诊断设备质量以及缩短采集时间。后者对于诊断胎儿异常尤为关键，因为这需要在尽可能短的时间内获得最佳图像质量。本文旨在开发一种MRI胎儿模型，并确定最能模拟其内部器官磁共振（MR）特征的材料。未来模型的特点将包括模拟胎儿肢体运动。
以一名妊娠20周3天的孕妇的单次MRI研究作为参考并用于图像分割。将匿名的医学数字成像和通信（DICOM）文件导入3D Slicer v. 5.2.1，用于分割子宫、胎儿和内部器官。基于所进行的分割，获得了一个三维模型，用于在3D打印机上打印。模具在Anycubic Photon M3 Max打印机上进行3D打印。本文展示了用于模拟胎儿器官弛豫时间的组合物的选择和制造。给出了乳液以及基于卡拉胶和琼脂的水凝胶的配方。所选组合物用于填充3D打印模型。
统计分析表明，在对一名妊娠20周3天的孕妇和一个胎儿模型进行扫描所获得的绝对和相对信号值方面，没有显著差异。
在研究过程中，构建了一个人体胎儿模型，填充了弛豫时间T1和T2与相应组织对照值相似的组合物。该模型可用于建立和优化胎儿MRI协议、培训和教育医学生、住院医师、研究生以及X射线技术人员，还可用于及时控制图像质量和设备适用性。
