Kawano Yutaka, Watanabe Nanae, Nishiyama Masahiko, Ohmura Tousei, Mihara Hiroyoshi, Ono Kaoru, Tanaka Maki, Sato Yasushi, Tomonari Tetsu, Takeda Hidekatsu, Takayama Tetsuji
Department of Community Medicine and Medical Science, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Palliat Med Rep. 2024 Aug 23;5(1):381-386. doi: 10.1089/pmr.2024.0041. eCollection 2024.
Cancer-related fatigue (CRF) is a major obstacle to quality of life. Harms (ASH) is available as a botanical adaptogen food worldwide.
This study aimed to assess the feasibility and safety of ASH in patients with CRF.
Fifteen patients with CRF consumed ASH drink for 28 days. The primary endpoint was the completion rate of the study, and the secondary endpoints were changes in brief fatigue inventory (BFI), oxidative stress markers, and adverse events.
Seven patients successfully completed the study. Four patients who had BFI <5.5 at enrollment revealed a decrease in BFI. The biological antioxidant potential/diacron-reactive oxygen metabolites ratio, potential antioxidant capacity, was increased but not significant ( = 0.063). No adverse events attributable to ASH were observed.
Approximately 50% patients were successful in consuming ASH for 28 days. Patients with mild CRF showed improvement by using ASH. However, further investigations are needed to validate these findings.
癌症相关疲劳（CRF）是影响生活质量的主要障碍。南非醉茄（ASH）作为一种植物适应原性食品在全球范围内都有。
本研究旨在评估南非醉茄对CRF患者的可行性和安全性。
15例CRF患者饮用南非醉茄饮料28天。主要终点是研究完成率，次要终点是简明疲劳量表（BFI）、氧化应激标志物和不良事件的变化。
7例患者成功完成研究。4例入组时BFI<5.5的患者BFI有所下降。生物抗氧化能力/二乙酰反应性氧代谢产物比值，即潜在抗氧化能力有所增加，但不显著（P=0.063）。未观察到归因于南非醉茄的不良事件。
约50%的患者成功饮用南非醉茄28天。轻度CRF患者使用南非醉茄后有所改善。然而，需要进一步研究来验证这些发现。
