Getie Sisay, Wondimeneh Yitayih, Getnet Gebeyaw, Workineh Meseret, Worku Ligabaw, Kassu Afework, Moges Beyene
Department of Medical Parasitology, School of Medicine and Health Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Department of Immunology and Molecular Biology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
BMC Res Notes. 2015 Sep 28;8:480. doi: 10.1186/s13104-015-1468-2.
In Ethiopia, where malaria and schistosomiasis are co-endemic, co-infections are expected to be high. However, data about the prevalence of malaria-schistosomiasis co-infection and their clinical correlation is lacking. Therefore, the aim of this study was to assess prevalence of Schistosoma mansoni co-infection and associated clinical correlates in malaria patients.
A cross-sectional study was conducted in 2013 at Chwahit Health Center, in northwest Ethiopia. Blood film positive malaria patients (N = 205) were recruited for the study. Clinical, parasitological, hematological, and biochemical parameters were assessed from every study participant. Stool samples were also collected and processed with Kato-Katz technique to diagnose and classify intensity of Schistosoma mansoni.
The prevalence of Schistosoma mansoni and malaria co-infection was 19.5%. The age group of 16-20 years old was significantly associated with co-infection. Co-infected patients with a moderate-heavy egg burden of Schistosoma mansoni had significantly high mean Plasmodium parasitemia. On the other hand, age group of 6-10 years old and moderate-heavy Schistosoma mansoni co-infection were significantly associated with severe malaria.
Prevalence of malaria and Schistosoma mansoni co-infection in the study area was considerably high. Severity of malaria and parasitemia of Plasmodium were associated with certain age groups and intensity of concurrent Schistosoma mansoni. Further study is needed to explore the underlying mechanisms of interaction between malaria and Schistosoma mansoni.
在疟疾和血吸虫病共同流行的埃塞俄比亚，预计合并感染率会很高。然而，关于疟疾-血吸虫病合并感染的患病率及其临床相关性的数据却很缺乏。因此，本研究的目的是评估曼氏血吸虫合并感染在疟疾患者中的患病率及其相关临床特征。
2013年在埃塞俄比亚西北部的Chwahit健康中心进行了一项横断面研究。招募了血涂片阳性的疟疾患者（N = 205）参与研究。对每位研究参与者的临床、寄生虫学、血液学和生化参数进行了评估。还收集了粪便样本并采用加藤厚涂片法进行处理，以诊断和分级曼氏血吸虫感染强度。
曼氏血吸虫和疟疾合并感染的患病率为19.5%。16 - 20岁年龄组与合并感染显著相关。曼氏血吸虫虫卵负荷为中度至重度的合并感染患者，其疟原虫平均血症水平显著较高。另一方面，6 - 10岁年龄组和曼氏血吸虫中度至重度合并感染与重症疟疾显著相关。
研究区域内疟疾和曼氏血吸虫合并感染的患病率相当高。疟疾的严重程度和疟原虫血症与特定年龄组以及同时存在的曼氏血吸虫感染强度有关。需要进一步研究以探索疟疾和曼氏血吸虫之间相互作用的潜在机制。
