日本一家电池厂男性工人血液中相对较低的铅水平与尿液 δ-氨基乙酰丙酸浓度之间的关系。

Association between relatively low blood lead levels and urinary δ-aminolevulinic acid concentrations among male workers at a Japanese battery factory.

机构信息

Department of Preventive Medicine and Public Health, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.

Center for Perinatal, Pediatric, and Environmental Epidemiology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.

出版信息

J Occup Health. 2024 Jan 4;66(1). doi: 10.1093/joccuh/uiae056.

DOI:10.1093/joccuh/uiae056

PMID:39283726

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11472743/

Abstract

OBJECTIVES

Whether the known positive association between blood lead (PbB) levels and urinary δ-aminolevulinic acid (ALAU) also exists at relatively low PbB levels (<40 μg/dL) remains unclear. We aimed to investigate this association at lower PbB levels.

METHODS

We analyzed data from biannual medical examinations of workers at a Japanese factory from August 2013 to August 2023. We excluded records from female workers and those with missing data, resulting in a dataset consisting of 1396 records from 155 male workers. We employed mixed-effect linear regression models with a random intercept for workers and additional adjustments for age and smoking status.

RESULTS

The median PbB level across all the analyzed records was 8 μg/dL (range: 1-31 μg/dL). Significant positive associations were observed between PbB and ALAU, with a 1-unit increase in natural logarithm-transformed PbB corresponding to a 10.0% increase in ALAU (95% CI, 2.7%-17.9%). Categorized PbB analyses showed a 23.8% increase in ALAU (95% CI, 2.7%-49.2%) for PbB levels at 20-24 μg/dL and an 83.1% increase (95% CI, 30.1%-157.7%) for PbB levels ≥25 μg/dL, compared with those <5 μg/dL. The exposure-response curve analysis indicated a plateau followed by an increasing trend.

CONCLUSIONS

A positive and nonlinear association between PbB and ALAU levels was observed at relatively low PbB levels.

摘要

目的

血铅（PbB）水平与尿δ-氨基-γ-酮戊酸（ALAU）之间已知的正相关关系是否也存在于相对较低的 PbB 水平（<40μg/dL）尚不清楚。我们旨在研究较低 PbB 水平下的这种相关性。

方法

我们分析了 2013 年 8 月至 2023 年 8 月期间一家日本工厂员工的年度体检数据。我们排除了女性工人和数据缺失的记录，最终数据集包含了 155 名男性工人的 1396 份记录。我们采用了具有工人随机截距的混合效应线性回归模型，并进一步调整了年龄和吸烟状况。

结果

所有分析记录的 PbB 中位数水平为 8μg/dL（范围：1-31μg/dL）。PbB 与 ALAU 之间存在显著的正相关关系，自然对数转换后的 PbB 每增加 1 个单位，ALAU 增加 10.0%（95%CI，2.7%-17.9%）。分类的 PbB 分析显示，与 PbB<5μg/dL 相比，PbB 水平在 20-24μg/dL 时，ALAU 增加 23.8%（95%CI，2.7%-49.2%），PbB 水平≥25μg/dL 时，ALAU 增加 83.1%（95%CI，30.1%-157.7%）。暴露-反应曲线分析表明，在 PbB 水平较低时存在一个平台，随后呈上升趋势。