Schütz A, Skerfving S
Scand J Work Environ Health. 1976 Sep;2(3):176-84. doi: 10.5271/sjweh.2812.
During 1 h two healthy volunteers, not earlier exposed occupationally to lead, inhaled about 100 mg of lead as a mixture of lead oxides and lead sulfate. Maximum blood lead (PbB) concentrations of about 0.5 mg/1 and minimum blood cell delta-aminolevulinic acid dehydratase activities (ALAD) (6% of the preexposure values) were observed within 38 h after exposure. PbB and ALAD returned to preexposure levels after about 300 and 150 days. A highly significant correlation between ALAD and PbB was seen even at lead levels in the range 0.1-0.2 mg/1. Delta-aminolevulinic acid, coproporphyrin and lead in the urine (ALAU, CPU, and PbU, respectively) increased. The peak levels occurred after about 15 h for ALAU and CPU and after about 24 h for PbU. There was a very good correlation between log PbU and lin PbB. ALAU increased already at PbB levels of about 0.3 mg/1.
在1小时内，两名此前未在职业上接触过铅的健康志愿者吸入了约100毫克由氧化铅和硫酸铅组成的铅混合物。接触后38小时内观察到最大血铅（PbB）浓度约为0.5毫克/升，以及最低血细胞δ-氨基乙酰丙酸脱水酶活性（ALAD）（为接触前值的6%）。约300天和150天后，PbB和ALAD恢复到接触前水平。即使在铅水平为0.1 - 0.2毫克/升范围内，也观察到ALAD与PbB之间存在高度显著的相关性。尿中的δ-氨基乙酰丙酸、粪卟啉和铅（分别为ALAU、CPU和PbU）增加。ALAU和CPU的峰值水平在约15小时后出现，PbU的峰值水平在约24小时后出现。log PbU与lin PbB之间存在非常良好的相关性。在PbB水平约为0.3毫克/升时，ALAU就已增加。
