Lee B K
Br J Ind Med. 1982 Aug;39(3):283-9. doi: 10.1136/oem.39.3.283.
Two hundred and thirty-four lead workers employed in a storage battery factory in Korea were examined for lead in blood (PbB) and urine (PbU). delta-aminolaevulinic acid in urine (ALAU), coproporphyrin in urine (CPU), and haemoglobin. The dose-response relationship between PbB and ALAU suggested that a PbB below 50-60 micrograms/dl is a proper practical limit of biological monitoring for lead workers. The inter-relationship between PbB and ALAU or PbU was better explained by a segmental straight function than by a curvilinear function. Inclusion of data from workers whose PbB was below 30-40 micrograms/dl, if they comprise a relatively large proportion of the whole, seems to have a role as a dummy effect on the overall regression function causing the curvilinear trend. At a given blood lead concentration, the ALAU of lead workers increased with an increase in the duration of exposure. This could be explained by the chronic effect of lead on haem precursors. Semi-quantitative measurement of CPU still played an important part in the screening of lead workers due to its simplicity, showing high sensitivity (97.8%) in detecting lead workers with PbB of 60 micrograms/dl or over.
对韩国一家蓄电池厂的234名铅作业工人进行了血铅(PbB)、尿铅(PbU)、尿δ-氨基乙酰丙酸(ALAU)、尿粪卟啉(CPU)及血红蛋白检测。血铅与尿δ-氨基乙酰丙酸之间的剂量反应关系表明,血铅低于50 - 60微克/分升是铅作业工人生物监测的合适实际限值。血铅与尿δ-氨基乙酰丙酸或尿铅之间的相互关系用分段直线函数比用曲线函数能更好地解释。如果血铅低于30 - 40微克/分升的工人在总体中占比较大,将他们的数据纳入似乎会对导致曲线趋势的总体回归函数产生虚拟效应。在给定的血铅浓度下,铅作业工人的尿δ-氨基乙酰丙酸随接触时间的增加而升高。这可以用铅对血红素前体的慢性作用来解释。尿粪卟啉的半定量检测因其简单性,在铅作业工人筛查中仍发挥重要作用,对血铅60微克/分升及以上的铅作业工人检测灵敏度高达97.8%。