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人工耳蜗植入者中有无内耳畸形的不同电刺激听觉脑干反应(eCAP)类型:振幅增长函数、兴奋扩散、不应期恢复功能。

How differ eCAP types in cochlear implants users with and without inner ear malformations: amplitude growth function, spread of excitation, refractory recovery function.

作者信息

Cinar Betul Cicek, Özses Merve

机构信息

Department of Audiology, Hacettepe University, Ankara, Turkey.

出版信息

Eur Arch Otorhinolaryngol. 2025 Feb;282(2):731-742. doi: 10.1007/s00405-024-08971-9. Epub 2024 Sep 16.

DOI:10.1007/s00405-024-08971-9
PMID:39284939
Abstract

OBJECTIVES

Inner ear malformations (IEMs) may result in differences in outcomes of cochlear implant user. These differences could be observed in both behavioral and objective tests. eCAP is the most common used objective test in cochlear implants and have different presence rate in cochlear implant users with and without IEMs. This study aims to evaluate eCAP results from CI user with and without IEMs through different recoding methods; amplitude growth function, spreads of excitation and refractory recovery.

METHODS

There were 42 CI users (20 IEM&22 normal) above five-years old and with at least one year experience. Three different eCAP measurement was conducted at several intracochlear electrodes. Presence rate, threshold levels and amplitude were compared between groups.

RESULTS

For Amplitude growth function measurement, when the percentage of detected eCAP thresholds was analyzed between groups, there was a significant difference only for basal electrode and no significant difference for apical and middle electrodes. Similarly, the presence rate of RecF-eCAP for both groups were in a downward trend from apical to basal. However, there was no significant difference in AGF-eCAP and RecF-eCAP amplitudes between groups for the cochlea's apical, middle and basal region. Although the presence rate of SOE-eCAP was lower for IEM group, there was no significant difference in ECAP amplitudes for all maskers.

CONCLUSIONS

It could be inferred that even though the observable eCAP rate differed between these two groups when the observable eCAP was recorded, the IEM group produced eCAP with similar amplitudes to normal cochlea group.

摘要

目的

内耳畸形(IEMs)可能导致人工耳蜗使用者的结果存在差异。这些差异可在行为测试和客观测试中观察到。电刺激复合动作电位(eCAP)是人工耳蜗中最常用的客观测试,在有和没有IEMs的人工耳蜗使用者中具有不同的出现率。本研究旨在通过不同的记录方法评估有和没有IEMs的人工耳蜗使用者的eCAP结果;幅度增长函数、兴奋扩散和不应期恢复。

方法

有42名五岁以上且至少有一年使用经验的人工耳蜗使用者(20名有IEMs,22名正常)。在几个耳蜗内电极上进行了三种不同的eCAP测量。比较了两组之间的出现率、阈值水平和幅度。

结果

对于幅度增长函数测量,当分析两组之间检测到的eCAP阈值百分比时,仅基底电极存在显著差异,而顶电极和中间电极无显著差异。同样,两组的RecF-eCAP出现率从顶电极到基底电极呈下降趋势。然而,对于耳蜗的顶区、中区和基底区,两组之间的AGF-eCAP和RecF-eCAP幅度无显著差异。尽管IEM组的SOE-eCAP出现率较低,但所有掩蔽器的eCAP幅度无显著差异。

结论

可以推断,尽管在记录可观察到的eCAP时,这两组之间可观察到的eCAP率不同,但IEM组产生的eCAP幅度与正常耳蜗组相似。

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本文引用的文献

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Eur Arch Otorhinolaryngol. 2024 Jul;281(7):3491-3498. doi: 10.1007/s00405-024-08451-0. Epub 2024 Jan 19.
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Exponential fitting of spread of excitation response measurements in cochlear implants.人工耳蜗中兴奋反应测量传播的指数拟合
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The Effect of Aging on Auditory Nerve Function: Insights from Intraoperative eCAP Recordings in Cochlear Implant Users.
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Prediction of Auditory Performance in Cochlear Implants Using Machine Learning Methods: A Systematic Review.使用机器学习方法预测人工耳蜗的听觉性能:一项系统综述。
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衰老对听觉神经功能的影响:来自人工耳蜗使用者术中电刺激听觉脑干反应记录的见解
Otol Neurotol. 2023 Jun 1;44(5):447-452. doi: 10.1097/MAO.0000000000003862. Epub 2023 Apr 6.
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Short- and long-latency components of the eCAP reveal different refractory properties.eCAP 的短潜伏期和长潜伏期成分揭示了不同的不应期特性。
Hear Res. 2022 Jul;420:108522. doi: 10.1016/j.heares.2022.108522. Epub 2022 May 16.
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The effect of stimulus level on excitation patterns of individual electrode contacts in cochlear implants.刺激水平对人工耳蜗中单个电极触点兴奋模式的影响。
Hear Res. 2022 Jul;420:108490. doi: 10.1016/j.heares.2022.108490. Epub 2022 Mar 25.
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