Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Outpatient Emergency Department of Shanghai Children's Medical Center, shanghai, China.
Respir Res. 2024 Sep 16;25(1):340. doi: 10.1186/s12931-024-02938-4.
The reference values of eNO have certain differences among people of different countries and races. We aimed to obtain the reference value of eNO in healthy children and adolescents (6-18 years old) in China and to explore the associations between the reference values with ages, gender, heights, BMI, and regions.
We measured FeNO levels in 5949 healthy Chinese children and adolescents, FeNO and CaNO levels in 658 participants from 16 provinces of 7 administrative areas in China aged 6-18. All persons were studied after obtaining informed consent from children and their parents.
The mean FeNO of 5949 Chinese children and adolescents aged 6-18 years was 14.1 ppb, with a 95% confidence interval of 1-38.1 ppb. The mean FeNO of 658 persons was 6.9 ppb with a 95% upper confidence interval of 15.0 ppb, and the mean CaNO was 3.0 ppb with a 95% upper confidence interval of 11.2 ppb. In the 6-11 age group, age and height were correlated with the logarithm of FeNO (P < 0.001, P < 0.05). There was no significant correlation between the logarithm of FeNO and gender, age, height and BMI (all P > 0.05). The logarithm of CaNO was correlated with gender (P < 0.05). In the 12-18 age group, gender, height, and region were correlated with the logarithm of FeNO (all P < 0.001). There was only a weak correlation between the logarithm of FeNO and height (P < 0.001). The logarithm of CaNO was negatively correlated with age (P < 0.05).
Higher FeNO, FeNO and CaNO values were found in healthy children and adolescents in China compared with foreign reports, and is affected by age, height, gender, and region. This study provides useful references for clinical application of eNO in children, especially Asian children.
eNO 的参考值在不同国家和种族的人群中存在一定差异。本研究旨在获得中国健康儿童和青少年（6-18 岁）eNO 的参考值，并探讨参考值与年龄、性别、身高、BMI 和地区的关系。
我们测量了 5949 名中国健康儿童和青少年的 FeNO 水平，以及来自中国 7 个行政区域 16 个省份的 658 名 6-18 岁参与者的 FeNO 和 CaNO 水平。所有参与者均在获得儿童及其父母的知情同意后进行研究。
5949 名 6-18 岁中国儿童和青少年的平均 FeNO 为 14.1 ppb，95%置信区间为 1-38.1 ppb。658 名参与者的平均 FeNO 为 6.9 ppb，95%置信区间上限为 15.0 ppb，平均 CaNO 为 3.0 ppb，95%置信区间上限为 11.2 ppb。在 6-11 岁年龄组中，年龄和身高与 FeNO 的对数呈正相关（P<0.001，P<0.05）。FeNO 的对数与性别、年龄、身高和 BMI 均无显著相关性（均 P>0.05）。CaNO 的对数与性别相关（P<0.05）。在 12-18 岁年龄组中，性别、身高和地区与 FeNO 的对数呈正相关（均 P<0.001）。FeNO 的对数与身高仅呈弱相关（P<0.001）。CaNO 的对数与年龄呈负相关（P<0.05）。
与国外报道相比，中国健康儿童和青少年的 FeNO、FeNO 和 CaNO 值较高，且受年龄、身高、性别和地区的影响。本研究为 eNO 在儿童，特别是亚洲儿童中的临床应用提供了有用的参考。
