广泛的分子检测方法仅在蜱叮咬患者的游走性红斑活检组织和血液中鉴定出 种。
Broad range molecular detection methods identify only spp. in erythema migrans biopsies and blood of tick-bitten patients.
作者信息
Pérot Philippe, Tondeur Laura, Moutailler Sara, Chrétien Delphine, Corre-Catelin Nicole, Vayssier-Taussat Muriel, Eloit Marc, Chirouze Catherine, Cazorla Céline
机构信息
Pathogen Discovery Laboratory, Institut Pasteur, Université Paris Cité, F-75015 Paris, France.
Institut Pasteur, Université Paris Cité, The WOAH (OIE) Collaborating Center for the Detection and Identification in Humans of Emerging Animal Pathogens, F-75015 Paris, France.
出版信息
One Health. 2024 Aug 30;19:100886. doi: 10.1016/j.onehlt.2024.100886. eCollection 2024 Dec.
Abstract
In this multicenter study conducted in France, we challenged the hypothesis of the transmission of pathogens other than spp. in 22 patients developing erythema migrans following a tick bite. Using a combination of high-throughput microfluidic PCRs and agnostic metagenomics on skin biopsies and blood samples, no microorganisms other than spp. was found.
摘要
在法国开展的这项多中心研究中，我们对22例蜱叮咬后出现游走性红斑的患者感染伯氏疏螺旋体属以外病原体的假说进行了验证。通过对皮肤活检组织和血液样本联合使用高通量微流控PCR及非特异性宏基因组学方法，未发现除伯氏疏螺旋体属以外的微生物。
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