Kawai Masanobu, Baba Sachiko, Tanigawa Kanami, Ikehara Satoyo, Kawasaki Ryo, Iso Hiroyasu
Department of Molecular Genetics and Endocrinology, Research Institute, Osaka Women's and Children's Hospital, Izumi, Osaka 594-1101, Japan.
Department of Gastroenterology, Nutrition, and Endocrinology, Osaka Women's and Children's Hospital, Izumi, Osaka 594-1101, Japan.
J Clin Endocrinol Metab. 2025 May 19;110(6):e1866-e1873. doi: 10.1210/clinem/dgae647.
Adequate nighttime sleep duration has been considered beneficial for linear growth in children; however, there is limited and conflicting evidence regarding the association between sleep duration and subsequent linear growth.
To investigate the association between sleep duration at 1.5 years and height at 3 years of age.
The Japan Environment and Children's Study is a nationwide prospective birth cohort study. Data from 52 140 term singleton births born at an appropriate-for-gestational age without background disorders that could potentially affect linear growth in the analyses were included. Nighttime and total sleep durations were calculated based on a self-administered questionnaire completed by caregivers. Tall stature was defined as height at or above the 75th percentile among participants.
After adjustment for height at 1.5 years, sex, monthly age, mother's height, presence of siblings at 1.5 years, environmental tobacco smoke at 1.5 years, daily TV/DVD screen time at 2 years, attendance at nursery at 2 years, household annual income at birth, and parents' educational status, multivariate odds ratio (95% CI) for tall stature at 3 years were 1.09 (1.01-1.17), 1.09 (1.01-1.17), and 1.25 (1.14-1.37) for 9.5 or 10, 10.5 or 11, and ≥ 11.5 hours of nighttime sleep duration at 1.5 years, respectively, compared with those with ≤ 9 hours sleep (P for trend <.0001). Total sleep duration was not associated with tall stature.
This study underscores the importance of nighttime sleep duration, not total sleep duration, in the linear growth of very young children.
充足的夜间睡眠时间被认为对儿童的线性生长有益；然而，关于睡眠时间与随后的线性生长之间的关联，证据有限且相互矛盾。
研究1.5岁时的睡眠时间与3岁时身高之间的关联。
日本环境与儿童研究是一项全国性的前瞻性出生队列研究。纳入了52140例足月单胎出生、适于胎龄且无可能影响分析中线性生长的背景疾病的数据。夜间和总睡眠时间根据照料者填写的自填式问卷计算得出。高身材定义为参与者中身高处于或高于第75百分位数。
在对1.5岁时的身高、性别、月龄、母亲身高、1.5岁时有兄弟姐妹情况、1.5岁时环境烟草烟雾暴露、2岁时每日看电视/ DVD屏幕时间、2岁时上托儿所情况、出生时家庭年收入以及父母教育程度进行调整后，1.5岁时夜间睡眠时间为9.5或10、10.5或11以及≥11.5小时的儿童，与睡眠时间≤9小时的儿童相比，3岁时高身材的多变量优势比（95%CI）分别为1.09（1.01 - 1.17）、1.09（1.01 - 1.17）和1.25（1.14 - 1.37）（趋势P <.0001）。总睡眠时间与高身材无关。
本研究强调了夜间睡眠时间而非总睡眠时间对幼儿线性生长的重要性。
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