Soria Erika, Lu Qiusheng, Boswell Will, Du Kang, Xing Yanting, Boswell Mikki, Weldon Korri S, Lai Zhao, Savage Markita, Schartl Manfred, Lu Yuan
The Xiphophorus Genetic Stock Center, Texas State University, San Marcos, Texas, USA.
Beijing No. 7 Middle School, Beijing, China.
Pigment Cell Melanoma Res. 2025 Jan;38(1):e13196. doi: 10.1111/pcmr.13196. Epub 2024 Sep 17.
Genetic interactions are adaptive within a species. Hybridization can disrupt such species-specific genetic interactions and creates novel interactions that alter the hybrid progeny overall fitness. Hybrid incompatibility, which refers to degenerative genetic interactions that decrease the overall hybrid survival and sterility, is one of the results from combining two diverged genomes in hybrids. The discovery of spontaneous lethal tumorigenesis and underlying genetic interactions in select hybrids between diverged Xiphophorus species showed that lethal pathological process can result from degenerative genetic interactions. Such genetic interactions leading to lethal phenotype are thought to shield gene flow between diverged species. However, hybrids between certain Xiphophorus species do not develop such tumors. Here we report the identification of a locus residing in the genome of one Xiphophorus species that represses an oncogene from a different species. Our finding provides insights into normal and pathological pigment cell development, regulation and a molecular mechanism in hybrid incompatibility.
基因相互作用在一个物种内具有适应性。杂交会破坏这种物种特异性的基因相互作用，并产生新的相互作用，从而改变杂交后代的整体适应性。杂种不亲和性是指降低杂种整体存活率和不育性的退化性基因相互作用，是杂种中两个分化基因组结合的结果之一。在分化的剑尾鱼属物种之间的特定杂种中发现自发致死性肿瘤发生及潜在的基因相互作用，表明致死性病理过程可能源于退化性基因相互作用。这种导致致死表型的基因相互作用被认为会阻碍分化物种之间的基因流动。然而，某些剑尾鱼属物种之间的杂种不会发生此类肿瘤。在此，我们报告了在一个剑尾鱼属物种的基因组中鉴定出一个位点，该位点可抑制来自另一个物种的致癌基因。我们的发现为正常和病理性色素细胞发育、调控以及杂种不亲和性的分子机制提供了见解。
