Tachibana K, Mukai K, Hiraoka I, Moriguchi S, Takama S, Kishino Y
JPEN J Parenter Enteral Nutr. 1985 Jul-Aug;9(4):428-34. doi: 10.1177/0148607185009004428.
To investigate the effect of arginine-enriched solution on tumor growth and metastasis, rats were infused with solutions containing 5.5 and 0.66% arginine for 8 days. Infusions were started at the same time of subcutaneous transplant of Yoshida sarcoma. Arginine-rich solution suppressed tumor growth at an early stage and prevented metastases to the liver and kidney. In addition, arginine supplements enhanced the phagocytic activity of alveolar macrophages. It also resulted in maintenance of a positive nitrogen balance and prevented the increases in the levels of several amino acids observed in the control group. The suppressive effect of arginine-enriched solution on tumor growth may be due to its activation of the immunologic system, in which the phagocytic activity of macrophages probably participates.
为研究富含精氨酸的溶液对肿瘤生长和转移的影响，给大鼠输注含5.5%和0.66%精氨酸的溶液，持续8天。输注在吉田肉瘤皮下移植的同时开始。富含精氨酸的溶液在早期抑制肿瘤生长，并防止转移至肝脏和肾脏。此外，补充精氨酸增强了肺泡巨噬细胞的吞噬活性。它还导致维持正氮平衡，并防止对照组中观察到的几种氨基酸水平升高。富含精氨酸的溶液对肿瘤生长的抑制作用可能归因于其对免疫系统的激活，其中巨噬细胞的吞噬活性可能参与其中。
