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A model for a dual function of N-methyladenosine in R-loop regulation.

作者信息

Abakir Abdulkadir, Ruzov Alexey

机构信息

Altos Labs, Cambridge, UK.

Institute of Bioengineering, Research Center of Biotechnology, Russian Academy of Sciences, Moscow, Russia.

出版信息

Nat Genet. 2024 Oct;56(10):1995-1998. doi: 10.1038/s41588-024-01905-5.

DOI:10.1038/s41588-024-01905-5
PMID:39289548
Abstract
摘要

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Dual roles of N-methyladenosine in R-loop regulation of gene transcription and genome stability.N-甲基腺苷在基因转录的R环调控和基因组稳定性中的双重作用。
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本文引用的文献

1
Co-transcriptional R-loops-mediated epigenetic regulation drives growth retardation and docetaxel chemosensitivity enhancement in advanced prostate cancer.共转录R环介导的表观遗传调控驱动晚期前列腺癌的生长迟缓并增强多西他赛化疗敏感性。
Mol Cancer. 2024 Apr 24;23(1):79. doi: 10.1186/s12943-024-01994-0.
2
Impaired binding affinity of YTHDC1 with METTL3/METTL14 results in R-loop accumulation in myelodysplastic neoplasms with DDX41 mutation.YTHDC1 与 METTL3/METTL14 结合亲和力受损导致 DDX41 突变的骨髓增生异常肿瘤中 R 环积累。
Leukemia. 2024 Jun;38(6):1353-1364. doi: 10.1038/s41375-024-02228-4. Epub 2024 Mar 21.
3
m6A修饰与R环的动态相互作用:对基因组稳定性的影响
Epigenomes. 2025 Jun 11;9(2):21. doi: 10.3390/epigenomes9020021.
The ARID1A-METTL3-m6A axis ensures effective RNase H1-mediated resolution of R-loops and genome stability.
ARID1A-METTL3-m6A 轴确保了 RNase H1 介导的 R 环有效解旋和基因组稳定性。
Cell Rep. 2024 Feb 27;43(2):113779. doi: 10.1016/j.celrep.2024.113779. Epub 2024 Feb 13.
4
METTL3 drives telomere targeting of TERRA lncRNA through m6A-dependent R-loop formation: a therapeutic target for ALT-positive neuroblastoma.METTL3 通过依赖 m6A 的 R 环形成驱动 TERRA lncRNA 定位于端粒:ALT 阳性神经母细胞瘤的治疗靶点。
Nucleic Acids Res. 2024 Mar 21;52(5):2648-2671. doi: 10.1093/nar/gkad1242.
5
A common transcriptional mechanism involving R-loop and RNA abasic site regulates an enhancer RNA of APOE.一种常见的涉及 R 环和 RNA 脱碱基位点的转录机制调节 APOE 的增强子 RNA。
Nucleic Acids Res. 2022 Nov 28;50(21):12497-12514. doi: 10.1093/nar/gkac1107.
6
METTL3-mediated m6A modification stabilizes TERRA and maintains telomere stability.METTL3 介导的 m6A 修饰稳定 TERRA 并维持端粒稳定性。
Nucleic Acids Res. 2022 Nov 11;50(20):11619-11634. doi: 10.1093/nar/gkac1027.
7
R-loop resolution promotes co-transcriptional chromatin silencing.R 环解旋促进共转录染色质沉默。
Nat Commun. 2021 Mar 19;12(1):1790. doi: 10.1038/s41467-021-22083-6.
8
TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolution.张力增强结合蛋白(TonEBP)识别R环并启动m6A RNA甲基化以解决R环问题。
Nucleic Acids Res. 2021 Jan 11;49(1):269-284. doi: 10.1093/nar/gkaa1162.
9
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METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation.METTL3 和 N6-甲基腺苷通过调节 DNA-RNA 杂交积累促进同源重组介导的 DSB 修复。
Mol Cell. 2020 Aug 6;79(3):425-442.e7. doi: 10.1016/j.molcel.2020.06.017. Epub 2020 Jul 1.