Dong Jinrun, Niu Deqiong, Xiang Ping, Dao Zhonghai, Li Jing
College of Biological Science and Food Engineering, Southwest Forestry University, Kunming, China.
School of Ecology and Environment, Southwest Forestry University, Kunming, China.
Nat Prod Res. 2024 Sep 18:1-8. doi: 10.1080/14786419.2024.2404660.
Phytochemical investigation of the chloroform extract of the roots of (Asclepiadaceae) led to the isolation of a new cardiac aglycone, characterised as Cynanchin A (1), as well as one known cardenolide (2) and nine known C21 steroidal glycosides (3-10), Their structures were established by 1D and 2D NMR spectra referring to the literature, together with high-resolution mass spectrometric analysis. In the present research, the cytotoxic activities of the 11 compounds on five different human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480) were evaluated . Most of the tested compounds showed potent inhibitory activities towards the five cell lines.
对萝藦科（Asclepiadaceae）植物根部氯仿提取物进行的植物化学研究，导致分离出一种新的强心苷元，鉴定为鹅绒藤苷元A（1），以及一种已知的强心甾烯蟾毒类（2）和九种已知的C21甾体苷（3 - 10）。通过参考文献的一维和二维核磁共振光谱以及高分辨率质谱分析确定了它们的结构。在本研究中，评估了这11种化合物对五种不同人类癌细胞系（HL - 60、SMMC - 7721、A - 549、MCF - 7和SW480）的细胞毒性活性。大多数测试化合物对这五种细胞系显示出强效抑制活性。
