Pancotti Alexandre, de Barros Souza Mauro Vinícius, Santos Abreu Amanda, Rodrigues Rezende Stefane, Lázaro Moreli Marcos, Uceda Otero Enrique, Landers Richard, Soares Roniere, Wang Jiale
Universidade Federal de Jataí, Unidade Acadêmica Especial de Ciências Exatas e Tecnológicas, PPGCAS, Laboratório de Materiais, Rod. Br 364, km 168, CEP 75801-615, Jataí-GO, Brazil.
Universidade Federal de Jataí, Instituto de Ciências da Saúde - ICS, PPGCAS, Rod. Br 364, km 168, CEP 75801-615, Jataí-GO, Brazil.
Chem Biodivers. 2025 Jan;22(1):e202402048. doi: 10.1002/cbdv.202402048. Epub 2024 Nov 7.
In this work, bismuth ferrites (BFO) nanoparticles were produced in the form of using sol-gel technique, followed by annealing in a tube furnace in temperatures from 400 °C to 650 °C. X-ray diffraction (XRD) results showed the formation of small sizes nanoparticles (NPs) with high purity. Structural analysis displayed that annealing at 600 °C could make BFO NPs be fitted to rhombohedral space group (R3c), with small quantity of spurious phases. The sizes of the BFO nanoparticles determined by transmission electron microscopy (HRTEM) are between 50 to 100 nm. To evaluate the efficiency of BFO in antimicrobial susceptibility tests, the nanoparticles were dispersed through cand tested agar diffusion method and dilution in a 96 well plate using a Gram-positive strains (Staphylococcus aureus) and Gram negative strain (Escherichia coli). The antibacterial activity of the BFO NPs was tested at concentrations of 2 mg/mL with MIC greater than 60 μg/mL for both bacteria.
在本工作中，采用溶胶 - 凝胶技术制备了铋铁氧体（BFO）纳米颗粒，随后在管式炉中于400℃至650℃的温度下进行退火处理。X射线衍射（XRD）结果表明形成了高纯度的小尺寸纳米颗粒（NPs）。结构分析显示，在600℃退火可使BFO NPs符合菱面体空间群（R3c），且有少量杂相。通过透射电子显微镜（HRTEM）测定的BFO纳米颗粒尺寸在50至100nm之间。为了在抗菌药敏试验中评估BFO的效率，使用革兰氏阳性菌株（金黄色葡萄球菌）和革兰氏阴性菌株（大肠杆菌），通过琼脂扩散法和在96孔板中稀释的方式将纳米颗粒分散并进行测试。在浓度为2mg/mL时测试了BFO NPs的抗菌活性，两种细菌的最低抑菌浓度（MIC）均大于60μg/mL。
