Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
J Agric Food Chem. 2024 Oct 2;72(39):21667-21676. doi: 10.1021/acs.jafc.4c07686. Epub 2024 Sep 18.
Fungal secondary metabolites play a highly significant role in crop protection, which is related to their antifungal activity against agriculturally important phytopathogens. In fact, plant diseases caused by fungi including species belonging to the genera of , , and have become increasingly serious affecting crop yield and quality. Hence, there is increasing awareness by the scientific community of the importance of exploiting fungal products for finding new compounds able to inhibit phytopathogens. In this study several drimane-type sesquiterpenes have been detected for the first time as products of by GC-MS analysis of the organic extracts obtained from the mycelia and culture filtrates of the fungus grown on two different substrates. Seven pure drimane-type sesquiterpenes were also isolated and identified by spectroscopic methods. The inhibitory effects of the pure compounds have been investigated against three phytopathogenic fungi of agrarian crops (i.e., , , and f. sp. ). Among the drimane-type sesquiterpenes isolated in this study, 9,11-dihydroxy-6-oxodrim-7-ene is the most active against the three phytopathogens. Our findings also reveal the high sensitivity of to the isolated compounds. These results pave the way for future applications in agriculture of both and its metabolites.
真菌次生代谢产物在作物保护中起着非常重要的作用，这与它们对农业上重要的植物病原菌的抗真菌活性有关。事实上，由真菌引起的植物病害，包括属于 、 和 属的物种，已经变得越来越严重，影响了作物的产量和质量。因此，科学界越来越意识到利用真菌产物来寻找能够抑制植物病原菌的新化合物的重要性。在这项研究中，通过对在两种不同基质上生长的真菌的菌丝体和培养液提取物的有机提取物进行 GC-MS 分析，首次检测到几种裂环烯酮型倍半萜烯作为 的产物。还通过光谱方法分离和鉴定了七种纯裂环烯酮型倍半萜烯。研究了纯化合物对三种农业作物病原菌（即 、 和 f. sp. ）的抑制作用。在所研究的裂环烯酮型倍半萜烯中，9,11-二羟基-6-氧代裂环-7-烯对三种植物病原菌的活性最高。我们的研究结果还揭示了 对分离化合物的高敏感性。这些结果为未来在农业中应用 和其代谢物铺平了道路。
