Escuela de Obstetricia y Puericultura, Facultad de Medicina, Universidad de Valparaíso, Angamos 655, Reñaca, Viña del Mar 2520000, Chile.
Departamento de Química, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Avenida Leopoldo Carvallo 270, Playa Ancha, Valparaíso 2340000, Chile.
Molecules. 2018 Aug 16;23(8):2053. doi: 10.3390/molecules23082053.
Tomato crops can be affected by several infectious diseases produced by bacteria, fungi, and oomycetes. Four phytopathogens are of special concern because of the major economic losses they generate worldwide in tomato production; subsp. and pv. , causative agents behind two highly destructive diseases, bacterial canker and bacterial speck, respectively; fungus f. sp. that causes Fusarium Wilt, which strongly affects tomato crops; and finally, spp., which affect both potato and tomato crops. Polygodial (), drimenol (), isonordrimenone (), and nordrimenone () were studied against these four phytopathogenic microorganisms. Among them, compound , obtained from Forst, and synthetic compound are shown here to have potent activity. Most promisingly, the results showed that compounds and affect growth at minimal inhibitory concentrations (MIC) values of 16 and 32 µg/mL, respectively, and high antimycotic activity against and spp. with MIC of 64 µg/mL. The results of the present study suggest novel treatment alternatives with drimane compounds against bacterial and fungal plant pathogens.
番茄作物可能受到细菌、真菌和卵菌引起的几种传染病的影响。由于这四种植物病原菌在世界范围内的番茄生产中造成了重大经济损失，因此它们特别令人关注：分别是亚种和 pv. ，这是两种高度破坏性疾病——细菌性溃疡病和细菌性斑点病的病原体；引起枯萎病的真菌 f. sp. ，它对番茄作物有强烈影响；最后， spp. ，它同时影响土豆和番茄作物。对这四种植物病原菌微生物进行了研究，包括聚戊二烯（）、二甲烯醇（）、异诺二烯酮（）和诺二烯酮（）。其中，从 Forst 获得的化合物 和合成化合物 表现出很强的活性。最有希望的是，结果表明化合物 和 以最小抑制浓度（MIC）值 16 和 32 µg/mL 分别影响 生长，并且对 和 spp. 具有 64 µg/mL 的高抗真菌活性。本研究结果表明，二甲烯化合物是一种针对细菌和真菌植物病原体的新型治疗选择。
