Oh S Y, Miller L T
Am J Clin Nutr. 1985 Sep;42(3):421-31. doi: 10.1093/ajcn/42.3.421.
The effects of dietary cholesterol on plasma cholesterol levels, its distribution among lipoproteins, and apoproteins of high-density lipoprotein subclasses in individuals who did and did not demonstrate response in plasma cholesterol levels were studied in 21 healthy middle-aged men for 3 mo. After consumption of 3 eggs/day in addition to their habitual diets for 28 days, 21 subjects were divided into 8 hyper- and 13 hypo-responders. The average plasma cholesterol level of the 21 subjects was changed from 188 +/- 36 to 199 +/- 36 mg/100 ml over the 28-day classification period. During the same period the mean plasma cholesterol level of the hyper-responders was significantly increased (p less than 0.025) from 170 +/- 41 to 199 +/- 29 mg/100 ml while that of the hypo-responders fell slightly. The addition of six eggs to the daily diet of the hypo-responders did not alter the mean plasma cholesterol level but resulted in a wide difference in response of plasma cholesterol concentration. The 13 hypo-responders were divided into hypo-hyper-responders (n = 6) and hypo-hypo-responders (n = 7) depending upon the degree of change in plasma cholesterol level. The present study illustrated the variabilities of plasma cholesterol level among free-living subjects who demonstrated two-stage thresholds of response to dietary intake of cholesterol.
在21名健康中年男性中进行了为期3个月的研究，观察膳食胆固醇对血浆胆固醇水平、其在脂蛋白中的分布以及高密度脂蛋白亚类载脂蛋白的影响，这些男性在血浆胆固醇水平上有或没有表现出反应。在按照习惯饮食食用28天后，每天额外食用3个鸡蛋，21名受试者被分为8名高反应者和13名低反应者。在28天的分类期内，21名受试者的平均血浆胆固醇水平从188±36mg/100ml变为199±36mg/100ml。在同一时期，高反应者的平均血浆胆固醇水平从170±41mg/100ml显著升高（p<0.025）至199±29mg/100ml，而低反应者的平均血浆胆固醇水平略有下降。在低反应者的日常饮食中添加6个鸡蛋并没有改变平均血浆胆固醇水平，但导致血浆胆固醇浓度的反应存在很大差异。根据血浆胆固醇水平的变化程度，13名低反应者被分为低-高反应者（n=6）和低-低反应者（n=7）。本研究说明了自由生活受试者中血浆胆固醇水平的变异性，这些受试者对膳食胆固醇摄入表现出两阶段的反应阈值。
