胆汁酸作为银屑病炎症调节剂的新兴潜力
The Emerging Potential of Bile Acids as a Modulator of Psoriatic Inflammation.
作者信息
Wei Grace, Shi Zhenrui, Wu Xuesong, Hwang Samuel T
机构信息
Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Department of Dermatology, School of Medicine, University of California Davis, Sacramento, CA, USA.
出版信息
J Psoriasis Psoriatic Arthritis. 2023 Jul;8(3):118-123. doi: 10.1177/24755303231177965. Epub 2023 Jun 16.
BACKGROUND
Bile acids (BAs) are cholesterol-based amphipathic surfactants that are most widely known for their contributions to lipid metabolism, but more recently have been increasingly recognized as a key signaling molecule in inflammatory diseases as well as, potentially, psoriatic disease.
OBJECTIVE
This brief review reviews relevant literature in order to briefly describe the synthesis of bile acids and their subsequent metabolism and to analyze recent animal and human data that supports anti-inflammatory activity of some BAs in psoriasiform dermatitis.
METHODS
Pubmed and other public sources were used to survey the literature relevant to the topic of bile acids and their potential use in psoriasis.
CONCLUSION
There is clinical and preclinical evidence to support a potential role for BA Supplementation (or modulation BA metabolism and signaling) in the treatment of psoriasis.
背景
胆汁酸（BAs）是基于胆固醇的两亲性表面活性剂，最为人所知的是它们对脂质代谢的作用，但最近越来越被认为是炎症性疾病以及可能的银屑病疾病中的关键信号分子。
目的
本简要综述回顾相关文献，以简要描述胆汁酸的合成及其后续代谢，并分析支持某些胆汁酸在银屑病样皮炎中具有抗炎活性的近期动物和人体数据。
方法
使用PubMed和其他公共资源来检索与胆汁酸主题及其在银屑病中的潜在用途相关的文献。
结论
有临床和临床前证据支持补充胆汁酸（或调节胆汁酸代谢和信号传导）在银屑病治疗中的潜在作用。
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