Fu Junhao, Yu Min, Xu Wenxia, Yu Shian
Central Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
Department of Hepatobiliary and Pancreatic Surgery, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
Front Oncol. 2022 Jan 20;11:778258. doi: 10.3389/fonc.2021.778258. eCollection 2021.
Bile acids (BAs) were originally known as detergents to facilitate the digestion and absorption of lipids. And our current knowledge of BAs has been extended to potential carcinogenic or cancer suppressor factors due to constant research. In fact, BAs were regarded as a tumor promoters as early as the 1940s. Differential bile acid signals emitted by various bile acid profiles can produce distinct pathophysiological traits, thereby participating in the occurrence and development of tumors. Nevertheless, in recent years, more and more studies have noticed the value of BAs as therapeutic targets. And several studies have applied BAs as a therapeutic agent for various diseases including cancer. Based on the above evidence, we acknowledge that the role of BAs in cancer has yet to be exploited, although considerable efforts have been made to probe the functions of BAs. In this review, we describe the characteristics of BAs as a double-edged sword in cancer, hoping to provide references for future cancer treatments.
胆汁酸（BAs）最初被认为是促进脂质消化和吸收的洗涤剂。随着不断的研究，我们目前对胆汁酸的认识已扩展到潜在的致癌或癌症抑制因子。事实上，早在20世纪40年代，胆汁酸就被视为肿瘤促进剂。各种胆汁酸谱发出的不同胆汁酸信号可产生不同的病理生理特征，从而参与肿瘤的发生和发展。然而，近年来，越来越多的研究注意到胆汁酸作为治疗靶点的价值。并且一些研究已将胆汁酸用作包括癌症在内的各种疾病的治疗剂。基于上述证据，我们认识到，尽管已经做出了相当大的努力来探究胆汁酸的功能，但胆汁酸在癌症中的作用尚未得到充分利用。在这篇综述中，我们描述了胆汁酸在癌症中作为双刃剑的特征，希望为未来的癌症治疗提供参考。
