Chen Dongmei, He Jingquan, Li Jinping, Zou Qian, Si Jiawei, Guo Yatao, Yu Jiayu, Li Cheng, Wang Fang, Chan Tianlong, Shi Huijuan
Innovation Team for Skin Disease Diagnosis and Treatment Technology & Drug Discovery and Development, The General Hospital of Ningxia Medical University, Yinchuan, China.
Institute of Human Stem Cell Research, The General Hospital of Ningxia Medical University, Yinchuan, China.
Front Microbiol. 2021 Mar 16;12:643449. doi: 10.3389/fmicb.2021.643449. eCollection 2021.
Psoriasis is a chronic inflammatory skin disease that affects millions of people worldwide. There is still no effective approach for the clinical treatment of psoriasis. This is largely due to the lack of understanding of the pathological mechanism. Here, we comprehensively characterized the skin microbiome and plasma metabolome alterations of psoriasis patients. We observed that some pathogenic bacteria, including , were significantly increased in psoriasis patients. The metabolomics results showed alterations in some metabolic pathways, especially pathways for lipid metabolism. In addition, microbiome-specific metabolites, including bile acids and kynurenine, were significantly changed. Correlation analysis revealed the interplay between the skin microbiota and plasma metabolites, especially between and several lipids. Our results provide new evidence for the interplay between the skin microbiome and plasma metabolites, which is dramatically disrupted in psoriasis patients. This study also revealed the mechanism underlying the pathogenesis of psoriasis.
银屑病是一种慢性炎症性皮肤病，影响着全球数百万人。目前仍没有有效的银屑病临床治疗方法。这在很大程度上是由于对其病理机制缺乏了解。在此，我们全面表征了银屑病患者的皮肤微生物组和血浆代谢组变化。我们观察到，包括 在内的一些病原菌在银屑病患者中显著增加。代谢组学结果显示某些代谢途径发生了改变，尤其是脂质代谢途径。此外，微生物组特异性代谢产物，包括胆汁酸和犬尿氨酸，也发生了显著变化。相关性分析揭示了皮肤微生物群与血浆代谢产物之间的相互作用，尤其是 与几种脂质之间的相互作用。我们的结果为皮肤微生物组与血浆代谢产物之间的相互作用提供了新证据，这种相互作用在银屑病患者中受到了极大破坏。本研究还揭示了银屑病发病机制的潜在机制。
