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基于没食子酸和聚乙二醇的新型天然二酯的绿色合成。

Green synthesis of new and natural diester based on gallic acid and polyethylene glycol.

机构信息

Laboratoire de chimie des polymères, Université Oran1 Ahmed Benbella, BP 1524, El'Menouer, Oran, 31000, Algeria.

Centre de Recherche Scientifique et Technique en Analyses Physico-chimiques (CRAPC), BP 384-Bou-Ismail-RP, Tipaza, Algeria, 42004, Algeria.

出版信息

F1000Res. 2023 Oct 20;12:1384. doi: 10.12688/f1000research.139861.1. eCollection 2023.

DOI:10.12688/f1000research.139861.1
PMID:39296352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11408915/
Abstract

BACKGROUND

Antioxidant polyphenols like gallic acid (GA) and its esters called "gallates", which have health advantages for humans, have grown in significance in maintaining a healthy lifestyle and eating a significant amount of secondary plant phytochemicals. Here, for the first time, we suggest a green synthesis of a brand-new, all-natural diester based on gallic acid and polyethylene glycol.

METHODS

This di-gallate is created in a single step without the use of a solvent (solid-solid reaction). This reaction has a potential yield of up to 90%. The bathochromic shift of the absorption bands from 277 nm to 295 nm in the UV-VIS spectra was caused by the addition of PEG to gallic acid. To confirm the structure of this di-gallate; Fourier-transform infrared (FTIR) spectroscopy, proton and carbon nuclear magnetic resonance ( H and C NMR), the thermal stability identified by thermogravimetric analysis (TGA), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were all used to thoroughly analyze the manufactured product.

RESULTS AND CONCLUSIONS

The acquired results, when compared to the literature spectrums, supported the establishment of the di-ester structure and created new opportunities for a large number of applications.

摘要

背景

具有抗氧化特性的多酚类物质，如没食子酸（GA）及其酯类物质“没食子酸酯”，对人体健康有益，在维持健康生活方式和摄入大量次生植物植物化学物质方面的重要性日益增加。在这里，我们首次提出了一种基于没食子酸和聚乙二醇的全新、全天然二酯的绿色合成方法。

方法

该二酯通过一步反应合成，无需使用溶剂（固-固反应）。该反应的潜在产率高达 90%。在紫外可见光谱中，由于 PEG 的加入，吸收带从 277nm 红移到 295nm。为了确认这种二酯的结构，我们使用傅里叶变换红外（FTIR）光谱、质子和碳核磁共振（H 和 C NMR）、热重分析（TGA）、X 射线衍射（XRD）和扫描电子显微镜（SEM）等手段对合成产物进行了全面分析。

结果和结论

与文献光谱进行比较，获得的结果支持了二酯结构的确立，并为大量应用创造了新的机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbcf/11408915/9e7fcc13db81/f1000research-12-153173-g0010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbcf/11408915/2b68e2d0e4e1/f1000research-12-153173-g0005.jpg
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