Surya Chandana, Lakshminarayana Ashoka Babu Vechham, Ramesh Sameera Hammigi, Kunjiappan Selvaraj, Theivendren Panneerselvam, Santhana Krishna Kumar A, Ammunje Damodar Nayak, Pavadai Parasuraman
Department of Pharmacognosy, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore, Karnataka 560054, India.
Department of Pharmacology, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore, Karnataka 560054, India.
J Trace Elem Med Biol. 2024 Dec;86:127526. doi: 10.1016/j.jtemb.2024.127526. Epub 2024 Sep 15.
Breast cancer (BC) is the most prevalent cancer among women worldwide and poses significant treatment challenges. Traditional therapies often lead to adverse side effects and resistance, necessitating innovative approaches for effective management.
This review aims to explore the potential of copper nanoparticles (CuNPs) in enhancing breast cancer therapy through targeted drug delivery, improved imaging, and their antiangiogenic properties.
The review synthesizes existing literature on the efficacy of CuNPs in breast cancer treatment, addressing common challenges in nanotechnology, such as nanoparticle toxicity, scalability, and regulatory hurdles. It proposes a novel hybrid method that combines CuNPs with existing therapeutic modalities to optimize treatment outcomes.
CuNPs demonstrate the ability to selectively target cancer cells while sparing healthy tissues, leading to improved therapeutic efficacy. Their unique physicochemical properties facilitate efficient biodistribution and enhanced imaging capabilities. Additionally, CuNPs exhibit antiangiogenic activity, which can inhibit tumor growth by preventing the formation of new blood vessels.
The findings suggest that CuNPs represent a promising avenue for advancing breast cancer treatment. By addressing the limitations of current therapies and proposing innovative solutions, this review contributes valuable insights into the future of nanotechnology in oncology.
乳腺癌（BC）是全球女性中最常见的癌症，带来了重大的治疗挑战。传统疗法常常导致不良副作用和耐药性，因此需要创新方法来进行有效管理。
本综述旨在探讨铜纳米颗粒（CuNPs）通过靶向药物递送、改善成像及其抗血管生成特性来增强乳腺癌治疗的潜力。
该综述综合了关于CuNPs在乳腺癌治疗中疗效的现有文献，讨论了纳米技术中的常见挑战，如纳米颗粒毒性、可扩展性和监管障碍。它提出了一种将CuNPs与现有治疗方式相结合的新型混合方法，以优化治疗效果。
CuNPs显示出能够选择性地靶向癌细胞，同时保护健康组织，从而提高治疗效果。其独特的物理化学性质有助于实现高效的生物分布和增强的成像能力。此外，CuNPs具有抗血管生成活性，可通过阻止新血管形成来抑制肿瘤生长。
研究结果表明，CuNPs是推进乳腺癌治疗的一个有前景的途径。通过解决当前疗法的局限性并提出创新解决方案，本综述为纳米技术在肿瘤学领域的未来发展提供了有价值的见解。
