Rubin C T, Lanyon L E
Calcif Tissue Int. 1985 Jul;37(4):411-7. doi: 10.1007/BF02553711.
The in vivo remodeling behavior within a bone protected from natural loading was modified over an 8-week period by daily application of 100 consecutive 1 Hz load cycles engendering strains within the bone tissue of physiological rate and magnitude. This load regime resulted in a graded dose:response relationship between the peak strain magnitude and change in the mass of bone tissue present. Peak longitudinal strains below 0.001 were associated with bone loss which was achieved by increased remodeling activity, endosteal resorption, and increased intra-cortical porosis. Peak strains above 0.001 were associated with little change in intra-cortical remodeling activity but substantial periosteal and endosteal new bone formation.
在8周的时间里，通过每天连续施加100个1Hz的加载循环，使受到保护不承受自然负荷的骨骼内的体内重塑行为发生改变，这些加载循环在骨组织内产生生理速率和大小的应变。这种加载方式导致了峰值应变大小与现存骨组织质量变化之间的分级剂量反应关系。低于0.001的峰值纵向应变与骨质流失有关，这是通过增加重塑活动、骨内膜吸收和皮质内孔隙率增加实现的。高于0.001的峰值应变与皮质内重塑活动变化不大，但骨膜和骨内膜有大量新骨形成有关。
