Cartwright D P
Can Anaesth Soc J. 1985 Sep;32(5):479-83. doi: 10.1007/BF03010796.
Seventy-three patients were studied during and after anaesthesia with either alfentanil or halothane for surgical procedures of short duration. The procedures were minor gynaecological or minor urological procedures, involving males and females between the ages of 21 and 86 years. After pre-medication with lorazepam, anaesthesia was induced with methohexitone and continued with nitrous oxide and oxygen, supplemented with halothane (34 patients) or alfentanil (39 patients). Anaesthesia was generally smooth and uncomplicated except that at induction 22 of the patients receiving alfentanil became apnoeic for longer than 30 seconds. Spontaneous respiration resumed without the need for naloxone in any patients. After surgery, recovery of consciousness was significantly more rapid after alfentanil than after halothane (5.6 minutes versus 10.1 minutes). This study demonstrates that alfentanil can be a suitable alternative to conventional general anaesthesia for short cases and may have a useful place when rapid recovery and turnover of cases is important.
对73例患者在麻醉期间及麻醉后使用阿芬太尼或氟烷进行短时间外科手术。手术为小型妇科或小型泌尿外科手术,涉及年龄在21至86岁之间的男性和女性。在使用劳拉西泮进行术前用药后,用美索比妥诱导麻醉,并持续使用氧化亚氮和氧气,再辅以氟烷(34例患者)或阿芬太尼(39例患者)。麻醉总体平稳且无并发症,只是在诱导期,接受阿芬太尼的患者中有22例出现呼吸暂停超过30秒。所有患者均无需纳洛酮即恢复自主呼吸。术后,使用阿芬太尼后意识恢复明显比使用氟烷后更快(分别为5.6分钟和10.1分钟)。本研究表明,对于短时间手术,阿芬太尼可作为传统全身麻醉的合适替代药物,在病例快速恢复和周转很重要的情况下可能有其用武之地。