Division of Epidemiology, Department of Health Informatics and Public Health, Graduate School of Medicine, Tohoku University School of Public Health, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.
Eur J Nutr. 2022 Aug;61(5):2627-2637. doi: 10.1007/s00394-022-02843-w. Epub 2022 Mar 4.
Previous studies have investigated the association between dairy intake and functional disability, but their results were inconsistent. Our study aimed to investigate whether dairy intake may protect against incident functional disability among Japanese older adults.
We conducted a longitudinal analysis of dairy intake with incident functional disability in a prospective cohort study of 11,911 Japanese individuals aged ≥ 65 years who were followed up for 8.2 years on average. Data on milk, yogurt, and cheese intake were collected using a validated food frequency questionnaire. Total dairy intake was the sum of the daily intake of milk, yogurt, and cheese, which was sex-specifically categorized in quintiles. Data on functional disability were retrieved from the public Long-term Care Insurance database. The Cox proportional hazards model was used to estimate the multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (95%CIs) for incident functional disability.
During 97,234 person-years of follow-up, 4874 persons (40.9%) were ascertained as having functional disability. Our study suggested a null association between total dairy intake and incident risk of functional disability; compared to Q1 (the lowest quintile) group, the multivariable-adjusted HRs (95%CIs) were 0.96 (0.88-1.05) for Q2, 0.93 (0.85-1.02) for Q3, 0.93 (0.85-1.02) for Q4, and 1.01 (0.92-1.10) for Q5 (p-trend = 0.840). We did not find any associations between milk, yogurt, or cheese intake and incident risk of functional disability.
We found no evidence showing that dairy intake was associated with functional disability among Japanese older adults.
先前的研究调查了乳制品摄入与功能障碍之间的关联，但结果不一致。我们的研究旨在调查乳制品摄入是否可以预防日本老年人发生功能障碍。
我们对 11911 名年龄≥65 岁的日本成年人进行了一项纵向分析，这些人在平均 8.2 年的时间内接受了随访。使用经过验证的食物频率问卷收集了关于牛奶、酸奶和奶酪摄入的数据。乳制品总摄入量是牛奶、酸奶和奶酪每日摄入量的总和，根据性别分为五分位数。功能障碍的数据来自公共长期护理保险数据库。使用 Cox 比例风险模型估计多变量调整后的风险比（HR）和 95%置信区间（95%CI）。
在 97234 人年的随访期间，4874 人（40.9%）被确定为患有功能障碍。我们的研究表明，总乳制品摄入量与功能障碍的发生风险之间没有关联；与 Q1（最低五分位数）组相比，多变量调整后的 HR（95%CI）分别为 Q2（第 2 五分位数）0.96（0.88-1.05）、Q3（第 3 五分位数）0.93（0.85-1.02）、Q4（第 4 五分位数）0.93（0.85-1.02）和 Q5（第 5 五分位数）1.01（0.92-1.10）（p 趋势=0.840）。我们没有发现牛奶、酸奶或奶酪摄入与功能障碍发生风险之间的任何关联。
我们没有发现证据表明乳制品摄入与日本老年人的功能障碍有关。
