Xiao Gui Lian, Wang Tao, Kuang Jiong, Mai Wen Li, Liu Hua, Ma Shi Ping, Sohouli Mohammad Hassan, Fatahi Somaye, Li Chengwen, Zou Shufang
School of Basic Medicine, Southwest Medical University, Luzhou, Sichuan, China.
Function Center, School of Basic Medicine and Forensic Medicine, North Sichuan Medical University, Nanchong, Sichuan, China.
Acta Diabetol. 2024 Dec;61(12):1495-1510. doi: 10.1007/s00592-024-02362-6. Epub 2024 Sep 20.
Considering the impact of adipokines on metabolic syndrome-related disorders and even chronic illnesses, it would appear vital to look for efficient treatments for these variables. The goal of this study was to thoroughly examine how the ketogenic diet (KD) affects adipokines.
Using standard keywords, the databases Scopus, PubMed/Medline, Web of Science, Cochrane, and Embase were searched to find all controlled trials looking into how KD affected adipokines (leptin, adiponectin, and ghrelin). By using a random-effects model analysis, pooled weighted mean difference and 95% confidence intervals were obtained.
This article featured twenty-two studies. The combined results demonstrated that, as compared to the control group, leptin levels in all populations are significantly lower when KD is adhered to (WMD: - 0.14 ng/ml, 95% CI: - 8.66, - 3.61, P < 0.001). On the other hand, no discernible impact of this diet on ghrelin and adiponectin concentrations was noted. The subgroup analysis results demonstrated that the drop in leptin levels was considerably higher in persons with BMI > 30 kg/m and in trials that followed the KD for ≤ 8 weeks than in the other groups.
Generally speaking, this diet can be utilized as a potentially helpful supplementary therapy to improve this adipokine, given the significance that leptin plays on numerous metabolic illnesses.
考虑到脂肪因子对代谢综合征相关疾病甚至慢性疾病的影响，寻找针对这些变量的有效治疗方法似乎至关重要。本研究的目的是全面研究生酮饮食（KD）如何影响脂肪因子。
使用标准关键词，检索了Scopus、PubMed/Medline、Web of Science、Cochrane和Embase数据库，以查找所有研究KD对脂肪因子（瘦素、脂联素和胃饥饿素）影响的对照试验。通过随机效应模型分析，获得合并加权平均差和95%置信区间。
本文纳入了22项研究。综合结果表明，与对照组相比，坚持KD时所有人群的瘦素水平均显著降低（加权平均差：-0.14 ng/ml，95%置信区间：-8.66，-3.61，P<0.001）。另一方面，未观察到这种饮食对胃饥饿素和脂联素浓度有明显影响。亚组分析结果表明，体重指数>30 kg/m²的人群以及KD持续时间≤8周的试验中，瘦素水平的下降幅度明显高于其他组。
一般来说，鉴于瘦素在多种代谢疾病中的重要作用，这种饮食可作为一种潜在有用的辅助治疗方法来改善这种脂肪因子。
