Aier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
Department of Ophthalmology, Shanghai Aier eye hospital, Shanghai, China.
PLoS One. 2024 Sep 20;19(9):e0310830. doi: 10.1371/journal.pone.0310830. eCollection 2024.
Utilizing a combination of micro-computed tomography (micro-CT) and anatomical techniques for the volumetric assessment of the eyeball and its constituents in Bama Miniature Pigs, New Zealand rabbits, and Sprague-Dawley(SD) rats.
Six Bama Miniature pigs, New Zealand rabbits, and SD rats were enrolled in the study. Micro-CT and gross volumetric estimation of ocular volume were employed to acquire data on ocular volume, anterior chamber volume, lens volume, and vitreous cavity volume for each eye.
The eyeball volume of pigs ranges from approximately 5.36 ± 0.27 to 5.55 ± 0.28 ml, the lens volume from approximately 0.33 ± 0.02 to 0.37 ± 0.06 ml, the anterior chamber volume from approximately 0.19 ± 0.05 to 0.28 ± 0.04 ml, and the vitreous volume is approximately 3.20 ± 0.18 ml. For rabbits, the eye volume, lens volume, anterior chamber volume, and vitreous volume range from approximately 3.02 ± 0.24 to 3.04 ± 0.24 ml, 0.41 ± 0.02 to 0.44 ± 0.02 ml, 0.23 ± 0.04 to 0.26 ± 0.05 ml, and 1.54 ± 0.14 ml, respectively. In SD rats, the volumes are 0.14 ± 0.02 to 0.15 ± 0.01 ml for the eyeball, 0.03 ± 0.00 to 0.03 ± 0.00 ml for the lens, 0.01 ± 0.00 to 0.01 ± 0.01 ml for the anterior chamber, and 0.04 ± 0.01 ml for the vitreous volume.
The integration of micro-CT and gross volumetric estimation of ocular volume proves effective in determining the eyeball volume in Bama Miniature Pigs, New Zealand rabbits, and SD rats. Understanding the volume distinctions within the eyeballs and their components among these experimental animals can lay the groundwork for ophthalmology-related drug research.
利用微计算机断层扫描（micro-CT）和解剖技术，对巴马小型猪、新西兰兔和 SD 大鼠的眼球及其成分进行容积评估。
本研究纳入了 6 头巴马小型猪、新西兰兔和 SD 大鼠。采用 micro-CT 和眼球总体积估计法，获取每只眼的眼球体积、前房体积、晶状体体积和玻璃体腔体积数据。
猪的眼球体积约为 5.36±0.27 至 5.55±0.28ml，晶状体体积约为 0.33±0.02 至 0.37±0.06ml，前房体积约为 0.19±0.05 至 0.28±0.04ml，玻璃体体积约为 3.20±0.18ml。对于兔，眼球体积、晶状体体积、前房体积和玻璃体体积分别约为 3.02±0.24 至 3.04±0.24ml、0.41±0.02 至 0.44±0.02ml、0.23±0.04 至 0.26±0.05ml 和 1.54±0.14ml。在 SD 大鼠中，眼球的体积分别为 0.14±0.02 至 0.15±0.01ml、晶状体为 0.03±0.00 至 0.03±0.00ml、前房为 0.01±0.00 至 0.01±0.01ml、玻璃体为 0.04±0.01ml。
微计算机断层扫描与眼球总体积估计的结合，可有效确定巴马小型猪、新西兰兔和 SD 大鼠的眼球体积。了解这些实验动物眼球及其成分的体积差异，可为眼科相关药物研究奠定基础。
