Inoue K
Gastroenterol Jpn. 1985 Jun;20(3):222-8. doi: 10.1007/BF02774708.
A comparative study of chronic hepatitis in two hospitals in Japan and England is reported. Patients seen in England came from a variety of countries and races. Type B chronic hepatitis was common in both hospitals. While CPH, CLH, and mild CAH were more frequently seen in cases from England, two thirds of the cases from Japan showed moderate or severe CAH. The most striking differences among the histological features were plasma cell infiltration and lymphoid follicle formation. The former was more frequent and conspicuous in cases from England, and the latter in non-A non-B cases from Japan. The incidence of bile duct damage and granulomatous lesions was different in the two hospitals. It was concluded that geographical differences should be taken into account when pathogenesis, histological definition, treatment and many other aspects of chronic hepatitis are assessed.
本文报道了日本和英国两家医院慢性肝炎的比较研究。在英国就诊的患者来自不同国家和种族。两家医院中B型慢性肝炎都很常见。虽然在英国的病例中，CPH、CLH和轻度CAH更为常见，但日本三分之二的病例表现为中度或重度CAH。组织学特征中最显著的差异是浆细胞浸润和淋巴滤泡形成。前者在英国的病例中更频繁且明显，而后者在日本的非甲非乙型病例中更明显。两家医院胆管损伤和肉芽肿性病变的发生率不同。得出的结论是，在评估慢性肝炎的发病机制、组织学定义、治疗及许多其他方面时，应考虑地域差异。
