Short Emma, Calimport Stuart, Bentley Barry
Cardiff School of Technologies, Cardiff Metropolitan University, Cardiff, UK.
Department of Cellular Pathology, Swansea Bay University Health Board, Swansea, UK.
Geroscience. 2025 Apr;47(2):1713-1720. doi: 10.1007/s11357-024-01315-9. Epub 2024 Sep 21.
Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health status, functional capacity and quality of life. It is therefore vital to develop comprehensive classification and staging systems for ageing-related pathologies, diseases and syndromes. This will allow societies to better identify, quantify, understand and meet the healthcare, workforce, well-being and socioeconomic needs of ageing populations, whilst supporting the development and utilisation of interventions to prevent or to slow, halt or reverse the progression of ageing-related pathologies. The foundation for developing such classification and staging systems is to define the scope of what constitutes an ageing-related pathology, disease or syndrome. To this end, a consensus meeting was hosted by the International Consortium to Classify Ageing-Related Pathologies (ICCARP), on February 19, 2024, in Cardiff, UK, and was attended by 150 recognised experts. Discussions and voting were centred on provisional criteria that had been distributed prior to the meeting. The participants debated and voted on these. Each criterion required a consensus agreement of ≥ 70% for approval. The accepted criteria for an ageing-related pathology, disease or syndrome were (1) develops and/or progresses with increasing chronological age; (2) should be associated with, or contribute to, functional decline or an increased susceptibility to functional decline and (3) evidenced by studies in humans. Criteria for an ageing-related pathology, disease or syndrome have been agreed by an international consortium of subject experts. These criteria will now be used by the ICCARP for the classification and ultimately staging of ageing-related pathologies, diseases and syndromes.
在全球范围内，人们的寿命在延长，但平均寿命的增加并不总是等同于健康寿命的增加。随着年龄的增长，与衰老相关疾病的患病率上升，会对健康状况、功能能力和生活质量产生重大影响。因此，为与衰老相关的病理、疾病和综合征制定全面的分类和分期系统至关重要。这将使社会能够更好地识别、量化、理解并满足老年人群的医疗保健、劳动力、福祉和社会经济需求，同时支持开发和利用干预措施来预防或减缓、阻止或逆转与衰老相关病理的进展。开发此类分类和分期系统的基础是界定构成与衰老相关病理、疾病或综合征的范围。为此，国际衰老相关病理分类联盟（ICCARP）于2024年2月19日在英国加的夫举办了一次共识会议，150位知名专家出席了会议。讨论和投票围绕会前分发的临时标准展开。与会者对这些标准进行了辩论和投票。每项标准都需要≥70%的共识同意才能获得批准。与衰老相关病理、疾病或综合征的公认标准为：（1）随着实足年龄的增加而发生和/或进展；（2）应与功能衰退相关或导致功能衰退，或易患功能衰退；（3）有人类研究证据支持。一个国际专家联盟已就与衰老相关病理、疾病或综合征的标准达成一致。这些标准现在将由ICCARP用于与衰老相关病理、疾病和综合征的分类及最终分期。
