Chen Qianqian, Liu Yanfei, Chen Qiwen, Li Mingfeng, Xu Lishang, Lin Bingyu, Tan Yifu, Liu Zhenbao
Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan Province, 410083, P. R. China.
Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan Province, 410013, P. R. China.
Small. 2024 Dec;20(49):e2405231. doi: 10.1002/smll.202405231. Epub 2024 Sep 23.
Cancer immunotherapy is a groundbreaking medical revolution and a paradigm shift from traditional cancer treatments, harnessing the power of the immune system to target and destroy cancer cells. In recent years, DNA nanostructures have emerged as prominent players in cancer immunotherapy, exhibiting immense potential due to their controllable structure, surface addressability, and biocompatibility. This review provides an overview of the various applications of DNA nanostructures, including scaffolded DNA, DNA hydrogels, tetrahedral DNA nanostructures, DNA origami, spherical nucleic acids, and other DNA-based nanostructures in cancer immunotherapy. These applications explore their roles in vaccine development, immune checkpoint blockade therapies, adoptive cellular therapies, and immune-combination therapies. Through rational design and optimization, DNA nanostructures significantly bolster the immunogenicity of the tumor microenvironment by facilitating antigen presentation, T-cell activation, tumor infiltration, and precise immune-mediated tumor killing. The integration of DNA nanostructures with cancer therapies ushers in a new era of cancer immunotherapy, offering renewed hope and strength in the battle against this formidable foe of human health.
癌症免疫疗法是一场开创性的医学革命，是从传统癌症治疗方法的范式转变，它利用免疫系统的力量来靶向和摧毁癌细胞。近年来，DNA纳米结构已成为癌症免疫疗法中的重要参与者，由于其可控的结构、表面可寻址性和生物相容性而展现出巨大潜力。本综述概述了DNA纳米结构的各种应用，包括支架DNA、DNA水凝胶、四面体DNA纳米结构、DNA折纸、球形核酸以及其他基于DNA的纳米结构在癌症免疫疗法中的应用。这些应用探索了它们在疫苗开发、免疫检查点阻断疗法、过继性细胞疗法和免疫联合疗法中的作用。通过合理设计和优化，DNA纳米结构通过促进抗原呈递、T细胞激活、肿瘤浸润和精确的免疫介导肿瘤杀伤，显著增强肿瘤微环境的免疫原性。DNA纳米结构与癌症疗法的整合开创了癌症免疫疗法的新时代，为对抗这一人类健康的强大敌人的战斗带来了新的希望和力量。
