Faustova Mariia, Dobrovolskyi Volodymyr, Loban' Galina, Bereza Yevhenii, Kotelnikova Aleksandra, Dobrovolskyi Oleksandr
Department of Microbiology, Virology and Immunology, Poltava State Medical University, Poltava, Ukraine.
Department of Surgery with Course of Dentistry, Pirogov Memorial National Medical University, Vinnytsia, Ukraine.
Front Oral Health. 2024 Sep 6;5:1446045. doi: 10.3389/froh.2024.1446045. eCollection 2024.
Physicians are increasingly prescribing antifungal drugs empirically to treat hospital-acquired infections quickly. This makes it obvious that fungal infections require more attention and systematic monitoring of resistance among them. The aim of the study was to identify antifungal drugs that retain their efficacy against isolates. There were 17 clinical isolates of obtained from patients and tested for susceptibility to antifungal drugs using the standard double dilution method. Amphotericin B, fluconazole, itraconazole, micafungin, and posaconazole were used in the study. To determine the groups of antimycotics to which the studied microorganisms retain sensitivity, a hierarchical cluster analysis was performed using the Ward's method. The tested representatives of the genus showed the lowest sensitivity to fluconazole. The efficacy of amphotericin B and itraconazole was almost at the same level. In turn, micafungin and posaconazole showed the best results against . Ward's cluster analysis combined the results of susceptibility to fluconazole, micafungin and itraconazole by the highest mathematical similarity. Amphotericin B and posaconazole were combined into one cluster due to their better efficacy against isolates.
医生越来越多地凭经验开抗真菌药物，以便快速治疗医院获得性感染。这表明真菌感染需要更多关注以及对其耐药性进行系统监测。该研究的目的是确定对分离株仍保持疗效的抗真菌药物。从患者身上获取了17株临床分离株，并使用标准双倍稀释法检测其对抗真菌药物的敏感性。该研究使用了两性霉素B、氟康唑、伊曲康唑、米卡芬净和泊沙康唑。为了确定所研究的微生物对哪些抗真菌药物组仍保持敏感性，使用沃德法进行了层次聚类分析。所测试的该属代表对氟康唑的敏感性最低。两性霉素B和伊曲康唑的疗效几乎处于同一水平。相反，米卡芬净和泊沙康唑对……显示出最佳效果。沃德聚类分析通过最高的数学相似性将对氟康唑、米卡芬净和伊曲康唑的敏感性结果进行了合并。两性霉素B和泊沙康唑由于对分离株有更好的疗效而被合并为一个聚类。
