ISEC Lisboa-Instituto de Educação e Ciência de Lisboa, 1750-179 Lisboa, Portugal.
Global Research and Development, Menicon Co. Ltd, Nagoya, Japan.
J Optom. 2024 Oct-Dec;17(4):100522. doi: 10.1016/j.optom.2024.100522. Epub 2024 Sep 23.
To assess differences in corneal higher-order aberrations (i.e., HOAs) between six different types of irregular corneas (i.e, keratoconus (KC), keratoglobus (KG), pellucid marginal degeneration (PMD), laser-assisted in situ keratomileusis (LASIK), penetrating keratoplasty (PK), and intrastromal corneal ring segments (ICRS)).
Corneal aberration data from the 3 and 4 order together with secondary vertical and horizontal coma, and secondary spherical aberration were retrospectively retrieved from a corneal tomographer and compared between irregular cornea types and for 3-, 5-, and 7-mm pupil diameters.
Significant differences were observed in vertical coma, oblique trefoil, secondary oblique astigmatism, primary spherical, and secondary spherical between irregular cornea types across all three pupil sizes (all p≤0.025). Vertical coma consistently exhibited the greatest magnitude of HOA across all irregular cornea types and pupil diameters. For the larger pupil diameters (5 and 7 mm), the 3rd order aberrations (mainly coma-like), the 4th order aberrations (mainly spherical-like), and total HOA RMS were significantly lower in the LASIK group compared to all other irregular cornea types (all p≤0.003). Additionally, at pupil sizes of 5 and 7 mm, the 3rd, 4th, coma-like, spherical-like, and total HOA RMS were significantly lower in KC compared to the ICRS and PK groups (all p≤0.01). Furthermore, the 4th, spherical-like, and total HOA RMS were significantly lower in KC compared to KG at pupil diameters of 3 and 7 mm, 5 and 7 mm, and 7 mm, respectively (all p≤0.03).
Vertical coma was the most elevated HOA across all irregular cornea types and pupil diameters. Corneal aberrations were lower in LASIK and KC, and higher in KG and PK.
评估 6 种不同类型不规则角膜（即圆锥角膜（KC）、球形角膜（KG）、边缘性角膜营养不良（PMD）、准分子激光原位角膜磨镶术（LASIK）、穿透性角膜移植术（PK）和间质角膜环片段（ICRS））之间角膜高阶像差（HOA）的差异。
从角膜断层扫描仪中回顾性地检索了 3 阶和 4 阶以及次要垂直彗差、水平彗差和次要球差的角膜像差数据，并比较了不规则角膜类型之间以及 3、5 和 7mm 瞳孔直径之间的差异。
在所有三种瞳孔尺寸下（所有 p≤0.025），不规则角膜类型之间的垂直彗差、斜三叶、次要斜散光、初级球差和次级球差均存在显著差异。在所有不规则角膜类型和瞳孔直径中，垂直彗差始终表现出最大的 HOA 幅度。对于较大的瞳孔直径（5 和 7mm），LASIK 组的 3 阶像差（主要是彗差样）、4 阶像差（主要是球差样）和总 HOA RMS 明显低于所有其他不规则角膜类型（所有 p≤0.003）。此外，在 5 和 7mm 瞳孔尺寸下，KC 组的 3 阶、4 阶、彗差样、球差样和总 HOA RMS 均明显低于 ICRS 和 PK 组（所有 p≤0.01）。此外，在 3、7mm、5、7mm 和 7mm 瞳孔直径下，KC 组的 4 阶、球差样和总 HOA RMS 均明显低于 KG 组（所有 p≤0.03）。
在所有不规则角膜类型和瞳孔直径中，垂直彗差是最显著的 HOA。LASIK 和 KC 的角膜像差较低，而 KG 和 PK 的角膜像差较高。
