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美国成人人群中肾盂成形术治疗肾盂输尿管连接部梗阻,伴或不伴双 J 留置输尿管支架。基于保险索赔数据,探讨当代去除趋势、围手术期并发症、医疗保健费用和再干预率的时间。

Primary pyeloplasty for uretero-pelvic obstruction in the USA adult population with or without double-J indwelling ureteral stents. Insurance claims data on contemporary time to removal trends, perioperative complications, health care costs, and re-intervention rates.

机构信息

Department of Maternal-Infant and Urological Sciences, Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy -

Department of Urology, Stanford University School of Medicine, Stanford, CA, USA -

出版信息

Minerva Urol Nephrol. 2024 Oct;76(5):606-617. doi: 10.23736/S2724-6051.24.05834-8.

Abstract

BACKGROUND

Using a large population-based dataset, we primarily sought to compare postoperative complications, health-care expenditures, and re-intervention rates between patients diagnosed with ureteropelvic junction obstruction (UPJO) undergoing stented vs. non-stented pyeloplasty. The secondary objective was to investigate factors that influence the timing of DJ stent removal.

METHODS

Patients ≥18 years old with UPJO treated with primary open or minimally-invasive pyeloplasty were identified using the Merative™ Marketscan Databases between 2007-2021. Multivariable modeling was implemented to investigate the association between Double-J (DJ) stent placement and post-pyeloplasty complications, hospital costs, and re-intervention rates and the role of the perioperative predictors on time to DJ stent removal. Subgroup analyses stratified by ureteral stenting duration were additionally performed.

RESULTS

Out of 4872 patients who underwent primary pyeloplasty, 4154 (85.3%) had DJ placement. Postoperative complications were rare (N.=218, 4.47%) and not associated with ureteral stenting (odds ratio [OR]: 0.78, 95% confidence interval [CI]: 0.55-1.12). The median cost for in-hospital charges was $21,775, with DJ stent placement independently increasing the median aggregate amount (OR: 1.29, 95% CI: 1.09-1.53). Overall, re-interventions were performed in 21.18% of patients, with DJ stenting found to be protective (OR: 0.79, 95% CI: 0.66-0.96). Higher Charlson Comorbidity Index, longer hospital stay, and open surgical approach were independent predictors for prolonged DJ stenting time to removal.

CONCLUSIONS

Our study suggests that patients undergoing stent-less pyeloplasty did have a higher rate of secondary procedures, but not higher complications when compared to those undergoing stented procedures. Concurrently, the non-stented approach is associated with decreased health-care expenditures, despite the increased rates of secondary procedures.

摘要

背景

本研究主要通过利用大型基于人群的数据集,比较了诊断为肾盂输尿管连接部梗阻(UPJO)并接受支架置入或非支架置入肾盂成形术的患者的术后并发症、医疗支出和再干预率。次要目标是探讨影响 DJ 支架取出时间的因素。

方法

使用 Merative™ Marketscan 数据库,于 2007 年至 2021 年期间,确定了 4872 例接受原发性开放或微创肾盂成形术治疗的年龄≥18 岁的 UPJO 患者。采用多变量模型探讨 DJ 支架置入与肾盂成形术后并发症、住院费用和再干预率之间的关系,以及围手术期预测因素对 DJ 支架取出时间的影响。此外,还进行了按输尿管支架留置时间分层的亚组分析。

结果

在 4872 例接受原发性肾盂成形术的患者中,有 4154 例(85.3%)接受了 DJ 支架置入。术后并发症罕见(N=218,4.47%),且与输尿管支架置入无关(比值比[OR]:0.78,95%置信区间[CI]:0.55-1.12)。住院费用中位数为 21775 美元,DJ 支架置入独立增加了总费用中位数(OR:1.29,95% CI:1.09-1.53)。总体而言,21.18%的患者需要进行再次干预,DJ 支架置入具有保护作用(OR:0.79,95% CI:0.66-0.96)。较高的 Charlson 合并症指数、较长的住院时间和开放手术方式是 DJ 支架取出时间延长的独立预测因素。

结论

我们的研究表明,与接受支架置入术的患者相比,接受无支架肾盂成形术的患者虽有更高的二次手术率,但并发症发生率并无差异。同时,非支架置入方法与医疗支出减少相关,尽管二次手术率增加。

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