Alternative processing and developmental control of the transcripts of the Drosophila abl oncogene homologue.

Drosophila sequences homologous to the abl oncogene are located near the 5' end of a gene (Dash). The Dash gene is transcribed to give long RNAs (5-6 kb) and short RNAs (3.0 kb) that lack some of the internal exons of the gene including some of the sequences coding for the protein kinase domain. The gene is composed of at least five short exons and a long 3' exon. The 3' exon is processed in several alternative ways. It contains an intronic sequence which is spliced out in approximately 50% of the transcripts. S1 mapping shows the existence of five different 3' ends, presumed polyadenylation sites, differing by up to 1 kb. Three of these are maternal-specific while the other two are utilised during development. Dash RNA is most abundant in eggs and early embryos, becomes very rare during larval development and returns in a burst of activity in early pupae.