Radiation Dosimetry and Processing Group, Defence Laboratory, Defence Research and Development Organization, Jodhpur, India.
J Mater Sci Mater Med. 2012 Nov;23(11):2649-58. doi: 10.1007/s10856-012-4730-3. Epub 2012 Aug 11.
Hydrogels with polyvinyl pyrrolidone (PVP) and alginate were synthesized and silver nanoparticles were incorporated in hydrogel network using gamma radiation. PVP (10 and 15 %) in combination with 0.5 and 1 % alginate was gamma irradiated at different doses of 25 and 40 kGy. Maximum gel percent was obtained with 15 % PVP in combination with 0.5 % alginate. The fluid absorption capacity for the PVP/alginate hydrogels was about 1881-2361 % at 24 h. Moisture vapour transmission rate (MVTR) of hydrogels containing nanosilver at 24 h was 278.44 g/(m(2)h). The absorption capacity and moisture permeability of the PVP/alginate-nanosilver composite hydrogel dressings show the ability of the hydrogels to prevent fluid accumulation in exudating wound. The hydrogels containing nanosilver demonstrated strong antimicrobial effect and complete inhibition of microbial growth was observed with 70 ppm nanosilver dressings. PVP/alginate hydrogels containing nanosilver with efficient fluid handling capacity and antimicrobial activity was found suitable for use as wound dressing.
合成了具有聚乙烯吡咯烷酮（PVP）和海藻酸钠的水凝胶，并通过γ辐射将纳米银颗粒掺入水凝胶网络中。PVP（10%和 15%）与 0.5%和 1%的海藻酸钠组合，在 25 和 40 kGy 的不同剂量下进行γ辐射。当 PVP 与 0.5%的海藻酸钠结合使用时，15%的 PVP 凝胶百分率最高。PVP/海藻酸钠水凝胶在 24 小时时的流体吸收能力约为 1881-2361%。在 24 小时时，含纳米银的水凝胶的水蒸气透过率（MVTR）为 278.44 g/（m(2)h）。含纳米银的 PVP/海藻酸钠复合水凝胶敷料的吸收能力和水分渗透性表明水凝胶具有防止渗出性伤口积液的能力。含纳米银的水凝胶表现出很强的抗菌效果，在 70 ppm 纳米银敷料下观察到完全抑制微生物生长。具有高效流体处理能力和抗菌活性的含纳米银 PVP/海藻酸钠水凝胶适合用作伤口敷料。
