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非稳定甲亚胺叶立德与2-苯并噻唑胺的[3 + 2]环加成反应以制备咪唑烷衍生物。

[3 + 2] cycloaddition of nonstabilized azomethine ylides and 2-benzothiazolamines to access imidazolidine derivatives.

作者信息

Wang Kai-Kai, Li Yan-Li, Wang Ming-Yue, Jing Jun, Wang Zhan-Yong, Chen Rongxiang

机构信息

School of Pharmacy, Xinxiang University Xinxiang 453000 P. R. China

Key Laboratory of Nano-carbon Modified Film Technology Engineering of Henan Province Xinxiang 453000 P. R. China.

出版信息

RSC Adv. 2022 Oct 4;12(44):28295-28298. doi: 10.1039/d2ra04616d.

DOI:10.1039/d2ra04616d
PMID:36320509
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9531537/
Abstract

A simple and practical method for the construction of 1,3,5-trisubstituted imidazolidine derivatives [3 + 2] cycloaddition reaction has been developed. This reaction could smoothly proceed between nonstabilized azomethine ylides generated and 2-benzothiazolamines to deliver a wide scope of differently substituted imidazolidines in high yields (up to 98%). The structure of one example was confirmed by X-ray single-crystal structure analysis.

摘要

已经开发出一种用于构建1,3,5-三取代咪唑烷衍生物的简单实用的[3 + 2]环加成反应方法。该反应可以在生成的非稳定甲亚胺叶立德与2-苯并噻唑胺之间顺利进行，以高收率（高达98%）提供多种不同取代的咪唑烷。通过X射线单晶结构分析确定了一个实例的结构。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c248/9531537/fd262bf601ba/d2ra04616d-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c248/9531537/2efc50a70bb0/d2ra04616d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c248/9531537/8fa6130f43b0/d2ra04616d-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c248/9531537/f3ea650f3ae2/d2ra04616d-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c248/9531537/574775c25cc3/d2ra04616d-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c248/9531537/fd262bf601ba/d2ra04616d-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c248/9531537/2efc50a70bb0/d2ra04616d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c248/9531537/8fa6130f43b0/d2ra04616d-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c248/9531537/f3ea650f3ae2/d2ra04616d-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c248/9531537/574775c25cc3/d2ra04616d-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c248/9531537/fd262bf601ba/d2ra04616d-s4.jpg

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