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一种含疫苗的腮腺炎非均匀连续年龄结构模型。

A heterogeneous continuous age-structured model of mumps with vaccine.

作者信息

Azimaqin Nurbek, Li Yingke, Liu Xianning

机构信息

Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), School of Mathematics and Statistics, Southwest University, Chongqing, 400715, China.

College of Mathematics and Physics, Xinjiang Agricultural University, Urumqi, 830052, China.

出版信息

Infect Dis Model. 2024 Sep 13;10(1):75-98. doi: 10.1016/j.idm.2024.09.004. eCollection 2025 Mar.

Abstract

In classical mumps models, individuals are generally assumed to be uniformly mixed (homogeneous), ignoring population heterogeneity (preference, activity, etc.). Age is the key to catching mixed patterns in developing mathematical models for mumps. A continuous heterogeneous age-structured model for mumps with vaccines has been developed in this paper. The stability of age-structured models is a difficult question. An explicit formula of was defined for the various mixing modes (isolation, proportional and heterogeneous mixing) with or without the vaccine. The results show that the endemic steady state is unique and locally stable if  > 1 without any additional conditions. A number of numerical examples are given to support the theory.

摘要

在经典的腮腺炎模型中,通常假定个体是均匀混合的(同质的),而忽略了人群的异质性(偏好、活动等)。年龄是在开发腮腺炎数学模型时捕捉混合模式的关键因素。本文建立了一个包含疫苗的腮腺炎连续非均匀年龄结构模型。年龄结构模型的稳定性是一个难题。针对有无疫苗的各种混合模式(隔离、比例混合和非均匀混合)定义了一个明确的公式。结果表明,如果在没有任何附加条件的情况下(\cdots\gt1),则地方病稳态是唯一且局部稳定的。给出了一些数值例子来支持该理论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ec3/11424798/7575f9469c07/gr1.jpg

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