Kula Alexander J, Bartlett Deirdre
Division of Pediatric Nephrology, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 Chicago Ave, Chicago, Il, 60611, USA.
Pediatr Nephrol. 2025 Mar;40(3):651-660. doi: 10.1007/s00467-024-06517-z. Epub 2024 Sep 27.
Cardiorenal syndrome (CRS) refers to concomitant dysfunction of both the heart and kidneys. The pathology in CRS is bidirectional. Many individuals with kidney disease will develop cardiovascular complications. Conversely, rates of acute kidney injury and chronic kidney disease are high in cardiac patients. While our understanding of CRS has greatly increased over the past 15 years, most research has occurred in adult populations. Improving cardiorenal outcomes in children and adolescents requires increased collaboration and research that spans organ systems. The purpose of this review is to discuss key features of CRS and help bring to light future opportunities for pediatric-specific research.
心肾综合征（CRS）是指心脏和肾脏同时出现功能障碍。CRS的病理过程是双向的。许多肾病患者会出现心血管并发症。相反，心脏病患者中急性肾损伤和慢性肾病的发生率很高。尽管在过去15年里我们对CRS的认识有了很大提高，但大多数研究都是在成年人群体中进行的。改善儿童和青少年的心肾结局需要加强跨器官系统的合作与研究。本综述的目的是讨论CRS的关键特征，并揭示未来针对儿科的研究机会。
