Bai Xueqin, Guo Tao, Guan Xiaojun, Zhou Cheng, Wu Jingjing, Wu Haoting, Liu Xiaocao, Wu Chengqing, Chen Jingwen, Wen Jiaqi, Qin Jianmei, Tan Sijia, DuanMu Xiaojie, Gu Luyan, Gao Ting, Huang Peiyu, Zhang Baorong, Xu Xiaojun, Zheng Xiangwu, Zhang Minming
Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, No.88 Jiefang Road, Shangcheng District, Hangzhou, 310009, China.
Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Brain Imaging Behav. 2024 Dec;18(6):1438-1447. doi: 10.1007/s11682-024-00931-5. Epub 2024 Sep 27.
To explore the cortical microstructural alterations in Parkinson's disease (PD) at different stages. 149 PD patients and 76 healthy controls were included. PD patients were divided into early stage PD (EPD) (Hoehn-Yahr stage ≤ 2) and moderate-to-late stage PD (MLPD) (Hoehn-Yahr stage ≥ 2.5) according to their Hoehn-Yahr stages. All participants underwent two-shell diffusion MRI and the images were fitted to Neurite Orientation Dispersion and Density Imaging (NODDI) model to obtain the neurite density index (NDI) and orientation dispersion index (ODI) to reflect the cortical microstructure. We used gray matter-based spatial statistics method to compare the voxel-wise cortical NODDI metrics between groups. Partial correlation was used to correlate the NODDI metrics and global composite outcome in PD patients. Compared with healthy controls, EPD patients showed lower ODI in widespread regions, covering bilateral frontal, temporal, parietal and occipital cortices, as well as regional lower NDI in bilateral cingulate and frontal lobes. Compared with healthy controls, MLPD patients showed lower ODI and NDI in more widespread regions. Compared with EPD patients, MLPD patients showed lower ODI in bilateral temporal, parietal and occipital cortices, where the ODI values were negatively correlated with global composite outcome in PD patients. PD patients showed widespread cortical microstructural degeneration, characterized by reduced neurite density and orientation dispersion, and the cortical neuritic microstructure exhibit progressive degeneration during the progression of PD.
为探究帕金森病（PD）不同阶段的皮质微观结构改变。纳入了149例PD患者和76名健康对照者。根据Hoehn-Yahr分期，将PD患者分为早期PD（EPD）（Hoehn-Yahr分期≤2）和中晚期PD（MLPD）（Hoehn-Yahr分期≥2.5）。所有参与者均接受了双壳扩散磁共振成像，图像拟合到神经突方向离散度和密度成像（NODDI）模型，以获得神经突密度指数（NDI）和方向离散度指数（ODI），以反映皮质微观结构。我们采用基于灰质的空间统计学方法比较组间体素水平的皮质NODDI指标。使用偏相关分析来关联PD患者的NODDI指标和整体综合结局。与健康对照者相比，EPD患者在广泛区域表现出较低的ODI，覆盖双侧额叶、颞叶、顶叶和枕叶皮质，以及双侧扣带回和额叶区域较低的NDI。与健康对照者相比，MLPD患者在更广泛的区域表现出较低的ODI和NDI。与EPD患者相比，MLPD患者在双侧颞叶、顶叶和枕叶皮质表现出较低的ODI，其中ODI值与PD患者的整体综合结局呈负相关。PD患者表现出广泛的皮质微观结构退变，其特征为神经突密度和方向离散度降低，并且在PD进展过程中皮质神经突微观结构呈现进行性退变。
