[反式茴香脑对肝脏单加氧酶系统的影响及其对多氯联苯的诱导作用]
[Effect of trans-anethole on liver monooxygenase system and its induction of polychlorinated diphenyls].
作者信息
Sinitskaia Z F, Lashneva N V, Chichilanova G V, Gadzhieva Z M, Shatrov G N, Tutelían V A
出版信息
Vopr Pitan. 1994(5):24-7.
Effect of trans-anetol (t-An) as nutritive addition to cytochrome P-450 containing system (MOS) of liver of rats was studied. It was shown, that t-An rendered inducing action to MOS, which depended on degree of action. It was established that simultaneous effect of t-An and mixture of polychlorinated diphenyles (sovol) modified inducing action of sovol to cytochrome P-450 system, Simultaneous effect of t-An and mixture of polychlorinated diphenyles increased hepatotoxic action of these xenobiotics.
研究了反式茴香脑（t-An）作为营养添加剂对大鼠肝脏含细胞色素P-450系统（MOS）的影响。结果表明，t-An对MOS具有诱导作用，该作用取决于作用程度。已确定t-An与多氯联苯混合物（sovol）的同时作用改变了sovol对细胞色素P-450系统的诱导作用，t-An与多氯联苯混合物的同时作用增加了这些异源生物素的肝毒性作用。
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