The Third Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan, China.
Yunnan University of Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan, China.
Medicine (Baltimore). 2024 Sep 27;103(39):e39834. doi: 10.1097/MD.0000000000039834.
Accumulating evidence indicates that individuals with chronic kidney disease (CKD) are at an increased risk of experiencing depressive disorders, which may accelerate its progression. However, the relationship between the triglyceride-glucose (TyG) index and depression in CKD individuals remains unclear. Therefore, this cross-sectional study aimed to assess whether such a relationship exists. To this end, the CKD cohort of the National Health and Nutrition Examination Survey from 2005 to 2020 was analyzed using multivariable logistic regression analyses and a generalized additive approach. A recursive algorithm was employed to pinpoint the turning point, constructing a dual-segment linear regression model. The study included 10,563 participants. After controlling for all variables, the odds ratios and 95% confidence intervals indicated a 1.24 (range, 1.09-1.42) relationship between the TyG index and depression in the CKD cohort. The findings underscored an asymmetrical association, with a pivotal value at a TyG index 9.29. Above this threshold, the adjusted odds ratio (95% confidence interval) was 1.10 (range, 0.93-1.31). This relationship was significant among the obese subgroups. The study results highlight the complex relationship between the TyG index and depression among American adults with CKD.
越来越多的证据表明，慢性肾脏病（CKD）患者发生抑郁障碍的风险增加，这可能加速其进展。然而，甘油三酯-葡萄糖（TyG）指数与 CKD 患者抑郁之间的关系尚不清楚。因此，本横断面研究旨在评估是否存在这种关系。为此，使用多变量逻辑回归分析和广义加性方法分析了 2005 年至 2020 年国家健康和营养检查调查的 CKD 队列。采用递归算法确定转折点，构建双段线性回归模型。该研究纳入了 10563 名参与者。在控制所有变量后，比值比和 95%置信区间表明 TyG 指数与 CKD 队列中抑郁之间存在 1.24（范围，1.09-1.42）的关系。研究结果强调了一种不对称的关联，在 TyG 指数为 9.29 时存在一个关键点。在此阈值之上，调整后的比值比（95%置信区间）为 1.10（范围，0.93-1.31）。这种关系在肥胖亚组中显著。研究结果突出了美国 CKD 成年患者中 TyG 指数与抑郁之间的复杂关系。
