Department of Physiology, University of Kentucky, Lexington, USA.
Department of Internal Medicine, University of Kentucky, Lexington, USA.
Commun Biol. 2024 Sep 27;7(1):1191. doi: 10.1038/s42003-024-06861-8.
Shift work and artificial light at night disrupt the entrainment of endogenous circadian rhythms in physiology and behavior to the day-night cycle. We hypothesized that exposure to dim light at night (dLAN) disrupts feeding rhythms, leading to sex-specific changes in autonomic signaling and day-night heart rate and blood pressure rhythms. Compared to mice housed in 12-hour light/12-hour dark cycles, mice exposed to dLAN showed reduced amplitudes in day-night feeding, heart rate, and blood pressure rhythms. In female mice, dLAN reduced the amplitude of day-night cardiovascular rhythms by decreasing the relative sympathetic regulation at night, while in male mice, it did so by increasing the relative sympathetic regulation during the daytime. Time-restricted feeding to the dim light cycle reversed these autonomic changes in both sexes. We conclude that dLAN induces sex-specific changes in autonomic regulation of heart rate and blood pressure, and time-restricted feeding may represent a chronotherapeutic strategy to mitigate the cardiovascular impact of light at night.
轮班工作和夜间人工光照会破坏生理和行为的内源性昼夜节律与日夜周期之间的同步。我们假设夜间低光照（dLAN）会破坏进食节律，导致自主信号和日夜心率及血压节律出现性别特异性变化。与在 12 小时光照/12 小时黑暗周期中饲养的小鼠相比，暴露于 dLAN 的小鼠的日夜进食、心率和血压节律振幅降低。在雌性小鼠中，dLAN 通过降低夜间相对交感神经调节来减少日夜心血管节律的振幅，而在雄性小鼠中，它通过增加白天的相对交感神经调节来实现这一点。限制在暗光照周期内进食可逆转这两种性别的自主变化。我们得出结论，dLAN 会引起心率和血压自主调节的性别特异性变化，而限时进食可能是减轻夜间光照对心血管影响的一种时间治疗策略。
