Viral Diversity Laboratory, Institute of Biological Sciences, Federal University of Pará, Belem, Pará, Brazil.
Medical Research Laboratory in Virology (LIM 52), Faculty of Medicine, University of São Paulo-Institute of Tropical Medicine de São Paulo, São Paulo, Brazil.
Virol J. 2024 Sep 27;21(1):229. doi: 10.1186/s12985-024-02507-7.
The objective of study was to characterize HPV in vaginal samples from women being seen at the Center for Reproductive Medicine and Infertility at Weill Cornell Medicine before and following ovarian stimulation. A total of 29 women made samples available for analysis by viral metagenomics. Eighteen women were HPV-positive, six (33.3%) at their initial visit and 15 (83.3%) following hormone stimulation (p = 0.0059). Pairwise comparison of nucleotide sequences and phylogenetic analysis showed the classification sequences into two genera: Alphapapillomavirus and Gammapapillomavirus. Sequences were from 8 HPV types: HPV 51 (n = 2), HPV 68 (n = 1), HPV 83 (n = 9), HPV 84 (n = 2), HPV 121 (n = 6), HPV 175 (n = 1) and HPV 190 (n = 1). Additionally, C16b and C30 likely represent new types. In summary, multiple HPV types are present in the vagina of reproductive age women and are induced by hormone used to stimulate ovulation.
本研究的目的是描述在威尔康奈尔医学院生殖医学和不孕不育中心接受卵巢刺激前和后，阴道样本中的 HPV 情况。共有 29 名女性提供样本，通过病毒宏基因组学进行分析。18 名女性 HPV 呈阳性，初次就诊时 6 名（33.3%），激素刺激后 15 名（83.3%）（p=0.0059）。核苷酸序列的成对比较和系统发育分析显示，分类序列分为两个属：α乳头瘤病毒属和γ乳头瘤病毒属。序列来自 8 种 HPV 类型：HPV 51（n=2）、HPV 68（n=1）、HPV 83（n=9）、HPV 84（n=2）、HPV 121（n=6）、HPV 175（n=1）和 HPV 190（n=1）。此外，C16b 和 C30 可能代表新的类型。总之，多种 HPV 类型存在于生育期女性的阴道中，并由用于刺激排卵的激素诱导。
