• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

从橄榄油副产品阿尔佩茹中提取的果胶-多酚复合物的健康促进特性：抗氧化、抗增殖和抗炎活性。

Health-Promoting Properties of Pectin-Polyphenol Complex Extracted from Olive Oil By-Product Alperujo: Antioxidant, Antiproliferative, and Anti-Inflammatory Activities.

作者信息

Bermúdez-Oria Alejandra, Castejón María Luisa, Rubio-Senent Fátima, Rodríguez-Gutiérrez Guillermo, Fernández-Bolaños Juan

机构信息

Department of Food Phytochemistry, Instituto de la Grasa (Spanish National Research Council, CSIC), Pablo de Olavide University Campus, Building 46, Ctra. de Utrera km. 1, 41013 Seville, Spain.

出版信息

Antioxidants (Basel). 2024 Aug 30;13(9):1066. doi: 10.3390/antiox13091066.

DOI:10.3390/antiox13091066
PMID:39334725
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11444132/
Abstract

This research explores the health-promoting properties of the pectin-polyphenol complex extracted from alperujo, a by-product of olive oil production. This study investigates the chemical composition and antioxidant activity of the extracts, revealing their high antioxidant activity in vitro. Cell viability assays conducted on colon carcinoma cells (Caco-2) demonstrate the inhibitory effect of the extracts on cell proliferation. However, the extracts do not affect the viability of differentiated Caco-2 cells, suggesting a selective antiproliferative action. Additionally, the extracts reduce intracellular reactive oxygen species (ROS) and nitrite (NO) production in LPS-stimulated murine peritoneal macrophages. Furthermore, the extracts exhibit anti-inflammatory effects by downregulating the secretion of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 in these macrophages. These findings highlight the potential of pectin-polyphenol complexes as functional ingredients with significant health benefits, demonstrating antioxidant, antiproliferative, and anti-inflammatory properties.

摘要

本研究探索了从橄榄油生产的副产品阿尔佩茹中提取的果胶-多酚复合物的健康促进特性。该研究调查了提取物的化学成分和抗氧化活性，揭示了它们在体外具有高抗氧化活性。对结肠癌细胞（Caco-2）进行的细胞活力测定表明提取物对细胞增殖具有抑制作用。然而，提取物不影响分化的Caco-2细胞的活力，表明其具有选择性抗增殖作用。此外，提取物可降低脂多糖刺激的小鼠腹腔巨噬细胞中细胞内活性氧（ROS）和亚硝酸盐（NO）的产生。此外，提取物通过下调这些巨噬细胞中促炎细胞因子TNF-α、IL-1β和IL-6的分泌而表现出抗炎作用。这些发现突出了果胶-多酚复合物作为具有显著健康益处的功能成分的潜力，证明了其抗氧化、抗增殖和抗炎特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c06/11444132/23a15cafaab6/antioxidants-13-01066-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c06/11444132/1c6034fa49c5/antioxidants-13-01066-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c06/11444132/c64851ad1365/antioxidants-13-01066-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c06/11444132/8d8bd4c46e69/antioxidants-13-01066-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c06/11444132/dff949e47f44/antioxidants-13-01066-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c06/11444132/23a15cafaab6/antioxidants-13-01066-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c06/11444132/1c6034fa49c5/antioxidants-13-01066-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c06/11444132/c64851ad1365/antioxidants-13-01066-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c06/11444132/8d8bd4c46e69/antioxidants-13-01066-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c06/11444132/dff949e47f44/antioxidants-13-01066-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c06/11444132/23a15cafaab6/antioxidants-13-01066-g005.jpg

相似文献

1
Health-Promoting Properties of Pectin-Polyphenol Complex Extracted from Olive Oil By-Product Alperujo: Antioxidant, Antiproliferative, and Anti-Inflammatory Activities.从橄榄油副产品阿尔佩茹中提取的果胶-多酚复合物的健康促进特性：抗氧化、抗增殖和抗炎活性。
Antioxidants (Basel). 2024 Aug 30;13(9):1066. doi: 10.3390/antiox13091066.
2
Effect of the Olive Oil Extraction Process on the Formation of Complex Pectin-Polyphenols and Their Antioxidant and Antiproliferative Activities.橄榄油提取工艺对复合果胶-多酚形成及其抗氧化和抗增殖活性的影响。
Antioxidants (Basel). 2021 Nov 23;10(12):1858. doi: 10.3390/antiox10121858.
3
Extraction of polyphenols associated with pectin from olive waste (alperujo) with choline chloride.用氯化胆碱从橄榄渣（alperujo）中提取与果胶相关的多酚。
Food Chem. 2023 Sep 1;419:136073. doi: 10.1016/j.foodchem.2023.136073. Epub 2023 Apr 5.
4
Pectin-rich extracts from olives inhibit proliferation of Caco-2 and THP-1 cells.橄榄富含果胶的提取物可抑制 Caco-2 和 THP-1 细胞的增殖。
Food Funct. 2019 Aug 1;10(8):4844-4853. doi: 10.1039/c9fo00917e. Epub 2019 Jul 19.
5
Enzyme-treated red rice (Oryza sativa L.) bran extracts mitigate inflammatory markers in RAW 264.7 macrophage cells and exhibit anti-inflammatory efficacy greater/comparable to ferulic acid, catechin, γ-tocopherol, and γ-oryzanol.酶解红米（Oryza sativa L.）糠提取物减轻 RAW 264.7 巨噬细胞炎症标志物的表达，并表现出比阿魏酸、儿茶素、γ-生育酚和γ-谷维素更强/相当的抗炎功效。
J Ethnopharmacol. 2024 Apr 6;323:117616. doi: 10.1016/j.jep.2023.117616. Epub 2023 Dec 22.
6
Effects of Extracts and Its Chemical Compounds on Proliferation of Cancer Cells and Cytokines Production of Lipopolysaccharide-activated THP-1 Macrophages.提取物及其化学成分对癌细胞增殖和脂多糖激活的THP-1巨噬细胞细胞因子产生的影响。
Pharmacogn Mag. 2017 Jul-Sep;13(51):393-399. doi: 10.4103/pm.pm_406_16. Epub 2017 Jul 19.
7
Volatile profiling coupled with multivariate analysis, antiproliferative and anti-inflammatory activities of rhizome essential oil of four Hedychium species from India.采用气质联用分析结合多元分析方法研究产自印度的四种姜黄属植物根茎精油的挥发性成分及其体外抗肿瘤和抗炎活性。
J Ethnopharmacol. 2023 Dec 5;317:116835. doi: 10.1016/j.jep.2023.116835. Epub 2023 Jun 22.
8
Supressive effect of maslinic acid from pomace olive oil on oxidative stress and cytokine production in stimulated murine macrophages.橄榄果渣油中齐墩果酸对刺激的小鼠巨噬细胞氧化应激和细胞因子产生的抑制作用。
Free Radic Res. 2006 Mar;40(3):295-302. doi: 10.1080/10715760500467935.
9
Antioxidant polyphenol-rich extracts from the medicinal plants Antirhea borbonica, Doratoxylon apetalum and Gouania mauritiana protect 3T3-L1 preadipocytes against H2O2, TNFα and LPS inflammatory mediators by regulating the expression of superoxide dismutase and NF-κB genes.抗氧化多酚丰富的提取物从药用植物 Antirhea borbonica、Doratoxylon apetalum 和 Gouania mauritiana 保护 3T3-L1 前脂肪细胞免受 H2O2、TNFα 和 LPS 炎症介质的影响，通过调节超氧化物歧化酶和 NF-κB 基因的表达。
J Inflamm (Lond). 2015 Feb 8;12:10. doi: 10.1186/s12950-015-0055-6. eCollection 2015.
10
The Polyphenolic Composition of Extracts Derived from Different Greek Extra Virgin Olive Oils Is Correlated with Their Antioxidant Potency.不同希腊特级初榨橄榄油提取物的多酚组成与其抗氧化能力相关。
Oxid Med Cell Longev. 2019 Mar 20;2019:1870965. doi: 10.1155/2019/1870965. eCollection 2019.

引用本文的文献

1
Prebiotic Potential of Dietary Polyphenols in Colorectal Cancer Immunomodulation.膳食多酚在结直肠癌免疫调节中的益生元潜力
Foods. 2025 Jul 7;14(13):2392. doi: 10.3390/foods14132392.

本文引用的文献

1
Immunomodulatory and Antioxidant Properties of Flour and Extracts Obtained by Green Extraction.绿色提取法获得的面粉和提取物的免疫调节及抗氧化特性
Curr Issues Mol Biol. 2023 Aug 22;45(9):6967-6985. doi: 10.3390/cimb45090440.
2
Extraction of polyphenols associated with pectin from olive waste (alperujo) with choline chloride.用氯化胆碱从橄榄渣（alperujo）中提取与果胶相关的多酚。
Food Chem. 2023 Sep 1;419:136073. doi: 10.1016/j.foodchem.2023.136073. Epub 2023 Apr 5.
3
Rhamnogalacturonan-I enriched pectin from steamed ginseng ameliorates lipid metabolism in type 2 diabetic rats via gut microbiota and AMPK pathway.
蒸制人参中富含鼠李半乳糖醛酸聚糖 I 的果胶通过肠道微生物群和 AMPK 途径改善 2 型糖尿病大鼠的脂质代谢。
J Ethnopharmacol. 2023 Jan 30;301:115862. doi: 10.1016/j.jep.2022.115862. Epub 2022 Oct 22.
4
Influence of glycosyl composition on the immunological activity of pectin and pectin-derived oligosaccharide.糖基组成对果胶和果胶衍生寡糖免疫活性的影响。
Int J Biol Macromol. 2022 Dec 1;222(Pt A):671-679. doi: 10.1016/j.ijbiomac.2022.09.193. Epub 2022 Sep 26.
5
Ligstroside aglycon, an extra virgin olive oil secoiridoid, prevents inflammation by regulation of MAPKs, JAK/STAT, NF-κB, Nrf2/HO-1, and NLRP3 inflammasome signaling pathways in LPS-stimulated murine peritoneal macrophages.橄榄苦苷配基，特级初榨橄榄油中的一种次生物，通过调节 LPS 刺激的鼠腹腔巨噬细胞中的 MAPKs、JAK/STAT、NF-κB、Nrf2/HO-1 和 NLRP3 炎性小体信号通路来预防炎症。
Food Funct. 2022 Oct 3;13(19):10200-10209. doi: 10.1039/d2fo00351a.
6
Effect of the Olive Oil Extraction Process on the Formation of Complex Pectin-Polyphenols and Their Antioxidant and Antiproliferative Activities.橄榄油提取工艺对复合果胶-多酚形成及其抗氧化和抗增殖活性的影响。
Antioxidants (Basel). 2021 Nov 23;10(12):1858. doi: 10.3390/antiox10121858.
7
The Role of Macrophages in the Host's Defense against .巨噬细胞在宿主抵御……中的作用
Pathogens. 2021 Jul 18;10(7):905. doi: 10.3390/pathogens10070905.
8
Anti-Inflammatory and Antioxidant Properties of Plant Extracts.植物提取物的抗炎和抗氧化特性。
Antioxidants (Basel). 2021 Jun 7;10(6):921. doi: 10.3390/antiox10060921.
9
Preparation, characterization, antioxidant and anti-inflammatory activities of acid-soluble pectin from okra (Abelmoschus esculentus L.).黄秋葵（Abelmoschus esculentus L.）酸溶性果胶的制备、表征、抗氧化和抗炎活性。
Int J Biol Macromol. 2021 Jun 30;181:824-834. doi: 10.1016/j.ijbiomac.2021.03.202. Epub 2021 Apr 6.
10
IL-6 in inflammation, autoimmunity and cancer.白细胞介素-6在炎症、自身免疫和癌症中的作用
Int Immunol. 2021 Mar 1;33(3):127-148. doi: 10.1093/intimm/dxaa078.