Min Ki Ha, Kim Koung Hee, Ki Mi-Ran, Pack Seung Pil
Institute of Industrial Technology, Korea University, Sejong-Ro 2511, Sejong 30019, Republic of Korea.
Department of Biotechnology and Bioinformatics, Korea University, Sejong-Ro 2511, Sejong 30019, Republic of Korea.
Antibiotics (Basel). 2024 Aug 23;13(9):794. doi: 10.3390/antibiotics13090794.
The emergence of drug resistance genes and the detrimental health effects caused by the overuse of antibiotics are increasingly prominent problems. There is an urgent need for effective strategies to antibiotics or antimicrobial resistance in the fields of biomedicine and therapeutics. The pathogen-killing ability of antimicrobial peptides (AMPs) is linked to their structure and physicochemical properties, including their conformation, electrical charges, hydrophilicity, and hydrophobicity. AMPs are a form of innate immune protection found in all life forms. A key aspect of the application of AMPs involves their potential to combat emerging antibiotic resistance; certain AMPs are effective against resistant microbial strains and can be modified through peptide engineering. This review summarizes the various strategies used to tackle antibiotic resistance, with a particular focus on the role of AMPs as effective antibiotic agents that enhance the host's immunological functions. Most of the recent studies on the properties and impregnation methods of AMPs, along with their biomedical applications, are discussed. This review provides researchers with insights into the latest advancements in AMP research, highlighting compelling evidence for the effectiveness of AMPs as antimicrobial agents.
耐药基因的出现以及抗生素过度使用所导致的有害健康影响，是日益突出的问题。在生物医学和治疗领域，迫切需要针对抗生素或抗菌耐药性的有效策略。抗菌肽（AMPs）的病原体杀伤能力与其结构和物理化学性质相关，包括其构象、电荷、亲水性和疏水性。AMPs是在所有生命形式中都存在的一种固有免疫保护形式。AMPs应用的一个关键方面涉及其对抗新出现的抗生素耐药性的潜力；某些AMPs对耐药微生物菌株有效，并且可以通过肽工程进行修饰。本综述总结了用于应对抗生素耐药性的各种策略，特别关注AMPs作为增强宿主免疫功能的有效抗生素剂的作用。讨论了最近关于AMPs的性质、浸渍方法及其生物医学应用的大多数研究。本综述为研究人员提供了关于AMPs研究最新进展的见解，突出了AMPs作为抗菌剂有效性的令人信服的证据。
