Bacsur Péter, Resál Tamás, Farkas Bernadett, Jójárt Boldizsár, Gyuris Zoltán, Jaksa Gábor, Pintér Lajos, Takács Bertalan, Pál Sára, Gácser Attila, Szántó Kata Judit, Rutka Mariann, Bor Renáta, Fábián Anna, Farkas Klaudia, Maléth József, Szepes Zoltán, Molnár Tamás, Bálint Anita
Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Kálvária Ave. 57, H-6725 Szeged, Hungary.
HCEMM-USZ Translational Colorectal Research Group, H-6725 Szeged, Hungary.
Biomedicines. 2024 Sep 14;12(9):2100. doi: 10.3390/biomedicines12092100.
Alterations to intestinal microbiota are assumed to occur in the pathogenesis of inflammatory bowel disease (IBD). This study aims to analyze the association of fecal microbiota composition, body composition, and lipid characteristics in patients with Crohn's disease (CD). In our cross-sectional study, patients with CD were enrolled and blood and fecal samples were collected. Clinical and endoscopic disease activity and body composition were assessed and laboratory tests were made. Fecal bacterial composition was analyzed using the shotgun method. Microbiota alterations based on obesity, lipid parameters, and disease characteristics were analyzed. In this study, 27 patients with CD were analyzed, of which 37.0% were obese based on visceral fat area (VFA). Beta diversities were higher in non-obese patients ( < 0.001), but relative abundances did not differ. had a higher abundance at a high cholesterol level than Bacillota ( = 0.001, = 0.0034). , , and alterations were correlated with triglyceride levels. Higher Clostridia ( = 0.009) and ( = 0.032) and lower ( = 0.035) were connected to high VFA. Disease activity was coupled with dysbiotic elements. Microbiota alterations in obesity highlight the importance of gut microbiota in diseases with a similar inflammatory background and project therapeutic options.
肠道微生物群的改变被认为发生在炎症性肠病（IBD）的发病机制中。本研究旨在分析克罗恩病（CD）患者粪便微生物群组成、身体成分和脂质特征之间的关联。在我们的横断面研究中，纳入了CD患者并采集了血液和粪便样本。评估了临床和内镜下的疾病活动度及身体成分，并进行了实验室检查。使用鸟枪法分析粪便细菌组成。分析了基于肥胖、脂质参数和疾病特征的微生物群改变。在本研究中，分析了27例CD患者，其中37.0%基于内脏脂肪面积（VFA）为肥胖。非肥胖患者的β多样性更高（<0.001），但相对丰度没有差异。在高胆固醇水平下，[此处原文可能缺失具体菌名]的丰度高于芽孢杆菌门（=0.001，=0.0034）。[此处原文可能缺失具体菌名]、[此处原文可能缺失具体菌名]和[此处原文可能缺失具体菌名]的改变与甘油三酯水平相关。较高的梭菌纲（=0.009）和[此处原文可能缺失具体菌名]（=0.032）以及较低的[此处原文可能缺失具体菌名]（=0.035）与高VFA相关。疾病活动度与生态失调因素相关。肥胖中的微生物群改变突出了肠道微生物群在具有相似炎症背景的疾病中的重要性，并提出了治疗选择。
