Yamazaki Kazuhisa
Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-Cho, Tsurumi-Ku, Yokohama, Kanagawa 230-0045, Japan.
Jpn Dent Sci Rev. 2023 Dec;59:273-280. doi: 10.1016/j.jdsr.2023.08.003. Epub 2023 Aug 28.
Substantial evidence suggests that periodontal disease increases the risk of developing and progressing extraoral manifestations such as diabetes, atherosclerosis, rheumatoid arthritis, and inflammatory bowel disease. The most probable causative mechanism behind this is the influx of bacteria and/or bacterial products (endotoxin) and inflammatory cytokines into the systemic circulation originating from inflamed periodontal tissues. However, recent studies have revealed that oral bacteria, especially periodontopathic bacteria, play a role in inducing dysbiosis of the gut microbiota resulting induction of gut dysbiosis-related pathology associated with systemic diseases. Conversely, the disruption of gut microbiota has been shown to have a negative impact on the pathogenesis of periodontal disease. Based on our study findings and the available literature, this review presents an overview of the relationship between periodontal disease and systemic health, highlighting the mouth-gut connection.
大量证据表明，牙周病会增加患口腔外疾病并使其病情进展的风险，如糖尿病、动脉粥样硬化、类风湿性关节炎和炎症性肠病。其背后最可能的致病机制是细菌和/或细菌产物（内毒素）以及炎症细胞因子从发炎的牙周组织进入体循环。然而，最近的研究表明，口腔细菌，尤其是牙周病原菌，在诱导肠道微生物群失调从而导致与全身疾病相关的肠道失调相关病理过程中发挥作用。相反，肠道微生物群的破坏已被证明对牙周病的发病机制有负面影响。基于我们的研究结果和现有文献，本综述概述了牙周病与全身健康之间的关系，突出了口腔与肠道的联系。
